Systemic inflammation may impair the function of Vitamin B6. There are also several kinds of medications, including NSAIDs and oral contraceptives, that interfere with vitamin B6 metabolism. Pregnancy and nursing increase B6 needs and low B6 can cause severe morning sickness.
"Vitamin B6, also called pyridoxine, is one of 8 B vitamins. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These B vitamins, often referred to as B complex vitamins, also help the body metabolize fats and protein. B complex vitamins are needed for healthy skin, hair, eyes, and liver. They also help the nervous system function properly. All B vitamins are water-soluble, meaning that the body does not store them."
"A new study shows a strong association between chronic inflammation and the essential vitamin found in foods such as lean meats, legumes, and vegetables. Researchers found that people with the lowest levels of vitamin B6 in their blood had the highest levels of chronic inflammation, based on a wide variety of indicators. Those with the most vitamin B6 circulating in the bloodstream were also the least likely to have indicators of inflammation."
"Other neurologic symptoms observed in severe vitamin B6 deficiency include irritability, depression, and confusion; additional symptoms include inflammation of the tongue, sores or ulcers of the mouth, and ulcers of the skin at the corners of the mouth."
"One large study found that women who took 500 mg of vitamin B6 daily along with 1,000 mcg of cyanocobalamin (vitamin B12) and 2,500 mcg of folic acid reduced their risk of developing AMD (age-related macular degeneration), an eye disease that can cause loss of vision."
The Linus Pauling Institute at Oregon State University
University of Maryland Medical Center
The Merck Manual
Intake of vitamins B6 and C and the risk of kidney stones in women.
"Urinary oxalate is an important determinant of calcium oxalate kidney stone formation. High doses of vitamin B6 may decrease oxalate production.. A high intake of vitamin B6 was inversely associated with risk of stone formation."
B6-responsive disorders: a model of vitamin dependency.