Dr Genuis conforms what many of us living with these symptoms already know- that many, if not most doctors do not believe that this constellation of symptoms is caused by physiological illness, but rather is a psychiatric somatic illness requiring anti-depressants for therapy. In his attempts to uncover a common physiological explanation, he says "A foray into the recesses of the scientific literature reveals discussion of a condition called sensitivity-related illness (SRI), with description of a credible causal mechanism to account for much of the emerging pandemic of multisystem health problems. This condition results when toxicant accrual within the human organism— typically from exposure to adverse chemicals—induces a state of immune dysregulation and hypersensitivity resulting in physiological disruption within various organ systems. The pathogenesis relates to an intriguing phenomenon called toxicant-induced loss of tolerance, a finding that represents a considerable advance in medical science pertaining to the origins and mechanisms of disease."
It seems that more and more doctors and researchers have begun paying attention to the co-morbidity of diseases and symptoms such as Mast Cell Disease (MCAD), Eosinophilic diseases (EGIDs and HES), other digestive disorders and symptoms, allergy and other forms of atopy such as eczema, migraines and other headaches, Ehlers-Danlos Syndrome (EDS) and other joint and connective tissue symptoms and disorders, psychiatric symptoms such as ADHD, OCD, panic disorders, and anxiety, neurological and neurodevelopmental disorders including autism and seizures, as well as many others. In particular, the three disorders of EDS, MCAS, and Dysautonomia (usually POTS) occur together so often that they are sometimes referred to as "the trifecta".
Researchers identify new spectrum disorder called ALPIM syndrome
"Panic disorder itself may be a predictor for a number of physical conditions previously considered unrelated to mental conditions, and for which there may be no or few biological markers," explains Dr. Coplan. In the study, published in the Journal of Neuropsychiatry and Clinical Neurosciences, the researchers proposed the existence of a spectrum syndrome comprising a core anxiety disorder and four related domains, for which they have coined the term ALPIM." These are: A = Anxiety disorder (mostly panic disorder); L = Ligamentous laxity (joint hypermobility syndrome, scoliosis, double-jointedness, mitral valve prolapse, easy bruising); P = Pain (fibromyalgia, migraine and chronic daily headache, irritable bowel syndrome, prostatitis/cystitis); I = Immune disorders (hypothyroidism, asthma, nasal allergies, chronic fatigue syndrome); and M = Mood disorders (major depression, Bipolar II and Bipolar III disorder, tachyphylaxis. Two thirds of patients in the study with mood disorder had diagnosable bipolar disorder and most of those patients had lost response to antidepressants).
A New Disease Cluster: Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, and Ehlers-Danlos Syndrome
Dr Meglathery, herself a patient with this combination of diagnoses, has developed a theory called The RCCX Theory that argues for an underlying genetic connection between these conditions.
Scientific Papers That Support These Connections:
Ehlers-Danlos Syndrome Hypermobility Type: A Genetic Predisposition to the Development of Various Functional Somatic Syndromes
Neurological manifestations of Ehlers-Danlos syndrome(s): A review
Chronic fatigue in Ehlers-Danlos syndrome-hypermobile type
Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome.
Neurodevelopmental attributes of joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type: Update and perspectives
Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls.
[Fibromyalgia: an unrecognized Ehlers-Danlos syndrome hypermobile type?].
High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
Eosinophilic gastrointestinal disorders associated with autoimmune connective tissue disease.
Involvement of mast cells in eosinophilic esophagitis.
Gastrointestinal symptoms associated with orthostatic intolerance.
Symptom overlap and comorbidity of irritable bowel syndrome with other conditions.
Characterizing Gulf War Illnesses: neurally mediated hypotension and postural tachycardia syndrome.
Neurally mediated hypotension and chronic fatigue syndrome.
Neurological Manifestations of Angioedema
Sleep research in autism and connective tissue
New Epidemics: The Possible Connection Between CFS/ME, Narcolepsy and PANS
New study shows severity of tinnitus (ringing in the ears) is related to emotional processing
Food Allergy Common in Joint Disorder
Kids with food-triggered eczema are at risk for developing life-threatening food allergy, study suggests
Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders
Psychiatric disorders and symptoms severity in pre-school children with cow's milk allergy.
Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses.
Cow's milk protein intolerance in adolescents and young adults with chronic fatigue syndrome.
Eczema Is Associated with Childhood Speech Disorder: A Retrospective Analysis from the National Survey of Children's Health and the National Health Interview Survey.