This blog is a way of sharing the information and resources that have helped me to recover my son Roo from an Autism Spectrum Disorder. What I have learned is to view our symptoms as the results of underlying biological cause, which can be identified and healed. I say "our symptoms" because I also have a neuro-immune disorder called Myalgic Encephalomyelitis.

And, of course, I am not a doctor (although I have been known to impersonate one while doing imaginative play with my son)- this is just our story and information that has been helpful or interesting to us. I hope it is helpful and interesting to you!


Wednesday, January 18, 2023

Non-pharmacological options for the Prevention and Treatment of COVID 19

There are quite a few options available to limit the spread of and severity of infection from SARS CoV-2 and other viruses that are safe, easy to get, inexpensive, and many are things a person can do themselves at home.

These include:

Black seed oil blocks the ACE2 receptor, which is one of the ways that SARS CoV 2 enters and infects cells. 

Povidone Iodine is one form of iodine that is readily available and has significant anti-microbial effects, including being anti-viral, and is quite safe.  It can be used as a mouthwash and gargle, a nasal rinse, for swabbing the ears, and for brushing teeth.  The povidone solution should be 0.5% to be effective. 

Saline can be used to rinse out the nasal passages and reduce viral load.  An easy option is to buy a can of saline mist at the drugstore, which can then be sprayed into the nostrils, or use a neti pot for a more thorough cleaning.  

Simple nasal wash can prevent hospitalization and deaths from COVID-19
"The researchers found that only 1.3 per cent of COVID-19 patients who underwent nasal wash required hospitalization, suggesting that they were more than eight times less likely to be hospitalized compared with the 11 per cent in the CDC dataset."
This article references the study:
Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients

Hydrogen Peroxide
How to Nebulize with (food-grade) Hydrogen Peroxide

mix 2 cups of distilled water with 1 teaspoon of Himalayan salt, 1 drop of iodine,  and 3/4 teaspoon of food grade hydrogen peroxide 12%.  Refrigerate this mixture.  Nebulize this every hour if you are very sick, or less often if you are less sick, such as every 4 to 6 hours.  You can also use this if you think you may have been exposed to COVID 19.  

To gargle with hydrogen peroxide mix one part H2O2 with 4 parts water and swish or gargle it for 30 seconds.

Another source discusses use of nebulizing hydrogen peroxide for general respiratory illnesses and COVID as well.  She prepares the solution to be nebulized by mixing hydrogen peroxide 3% with equal parts saline.  She will nebulize for about 2 minutes if she has been exposed to someone who is sick, or twice per day 4 minutes each time when she herself is sick.  For maintenance she uses it twice a week for about 2 minutes each time.  She points out that some people will have "die off" symptoms if they have other lingering or sub clinical infections in the mouth.  To clean the nebulizer, she rinses with hot water and then wipes out the insides with vinegar.  Lastly she suggests taking a dose (she doesn't say how much) of vitamin C after each time you nebulize.

Cardiopulmonary and hematological effects of infrared LED photobiomodulation in the treatment of SARS-COV2
"Post-treatment, the LED group showed a reduction in hospital discharge time and a statistically significant improvement for the following cardiopulmonary functions: Partial Oxygen Saturation, Tidal Volume, Maximum Inspiratory, and Expiratory Pressures, Respiratory Frequency, Heart Rate, and Systolic Blood Pressure (p < 0.05). Regarding blood count, it was observed that post-treatment, the LED group presented with significant differences in the count of leukocytes, neutrophils, and lymphocytes."
This is a MedCram lecture about this study

Supplements and Off-Label Medications:
Potential association of mast cells with coronavirus disease 2019

"Liposomal luteolin could be supplemented with the H1 receptor antagonist rupatadine (not available in the United States except if compounded), which has anti–platelet-activating factor and mast cell–inhibitory actions, and the H2 receptor antagonist, famotidine, which has been reported to be beneficial in COVID-19. In addition, supplementation with vitamin D3 could be useful, because it can reduce allergic inflammation and has been reported to be of benefit in COVID-19."

Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro (Chinese skullcap)
"We studied the anti-SARS-CoV-2 activity of S. baicalensis and its ingredients. We found that the ethanol extract of S. baicalensis and its major component, baicalein, inhibit SARS-CoV-2 3CLpro activity in vitro with IC50's of 8.52 µg/ml and 0.39 µM, respectively. Both of them inhibit the replication of SARS-CoV-2 in Vero cells with EC50's of 0.74 µg/ml and 2.9 µM, respectively. While baicalein is mainly active at the viral post-entry stage, the ethanol extract also inhibits viral entry. We further identified four baicalein analogues from other herbs that inhibit SARS-CoV-2 3CLpro activity at µM concentration. All the active compounds and the S. baicalensis extract also inhibit the SARS-CoV 3CLpro, demonstrating their potential as broad-spectrum anti-coronavirus drugs."

Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model
Zinc is an important mineral in facilitating our immune system's response to viral infections, and low zinc levels have been found to be a significant risk factor for catching COVID 19 and for this infection to be serious.  A zinc ionophore is something that transports zinc into the cell where it is needed to fight viruses.

I got my Taste and Smell back a year after having Covid!!! Here’s what I did.

Best Diet & Fast for COVID - NEW SCIENCE
The presenter fasted all day than had a large, vegetable-heavy dinner of salad and other vegetables.  She got through COVID in 5 days.  She also notes that fear and anger reduce our immune response and therefore can make us more susceptible to becoming sick.  She discusses several studies that provide evidence supporting the effectiveness of diet and fasting on COVID outcomes.

Diet Quality and Risk Severity of COVID 19: s prospective cohort study
This is a study that was published in the journal Gut in September of 2021 that followed over 500,000 people for a period of time, in which around 31,000 people got COVID.  Those who followed the diet, which included a high amount of plant-based foods, had a 50% lower risk of getting COVID. 

Diet may affect risk and severity of COVID-19
This is an article discussing the study linked to above discussed in more accessible layman's terms. 

Autophagy from intermittent fasting also aids the immune system in fighting off COVID 19 by stimulating immune function in many ways.  (quoted from the study below) "In autophagy, autophagosomes, a double membrane vesicles, engulf and fuse cytoplasmic elements that degraded and recycled the cargo to produce sugars, nucleosides/nucleotides, amino acids, and fatty acids. These vital components can be channeled to the other metabolic pathways for cellular utilization."

"In addition, autophagy is associated with various pathophysiological processes, such as cell survival, cell death, aging, and immunity. Autophagy is involved in the antigenic presentation of pathogen (for example, virus) components to the immune system. Autophagy modulates the constituents of immune system, including T and B lymphocytes, dendritic cells, macrophages, and natural killer (NK) cells. In innate as well as adaptive immune reactions, autophagy stimulates to maintain survival, homeostasis, proliferation, activation, as well as differentiation. Besides, autophagy also encourages immune-mediated cells to release antibodies and cytokines. During innate immunity, autophagy acts as a pattern of downstream receptors recognition through stimulation of the receptors of innate immunity containing nod-like receptors and toll-like receptors (TLR7), which triggers effector responses such as cytokine production, activation of NK T cell, and phagocytosis"

Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response
"As a healthy practice, calorie restriction in the form of intermittent fasting (IF) in several clinical settings has been reported to promote several health benefits, including priming of the immune response. This dietary restriction also activates autophagy, a cell surveillance system that boosts up immunity."

Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

How Long Do You Need to Fast for Autophagy?

General Immune Support

 A Doctor Explains How to Make the Safest Face Mask