[An attempt to block histamine release from basophils granulocytes with antibodies obtained as a result of long-term immunization]
"Microbes can play important role as hypersensitivity factor in some allergo-inflammatory processes. Bacterial products may act as basophil histamine liberators through immunological (IgE-mediated) and nonimmunological--particular lectin-sugar way.
Conclusions: 1. Bacteria induced basophil histamine release through two ways: immunological (IgE-mediated) and non-immunological (sugar-lectin interactions). 2. Non-immunological interactions played the main role in basophil histamine release induced by bacteria--both in normal individuals and asthmatic patients. 3. Sera of immunized with bacteria animals partially reduced basophil histamine release induced by homologous strains (Tab. 7). 4. An incubation of autologous bacterial strains with asthmatic patients's sera collected after autovaccines treatment has no influence on basophil histamine release induced by these microbes (Tab. 9). 5. There was no correlation between the skin reactivity to bacteria (both in healthy persons and in asthmatic patients) and the intensity of basophil histamine release induced by microbes."
Increased release of histamine in patients with respiratory symptoms related to perfume
“Perfume induces a dose-dependent non-IgE-mediated release
of histamine from human peripheral blood basophils. Increased basophil
reactivity to perfume was found in patients with respiratory symptoms related
to perfume.”
