This blog is a way of sharing the information and resources that have helped me to recover my son Roo from an Autism Spectrum Disorder. What I have learned is to view our symptoms as the results of underlying biological cause, which can be identified and healed. I say "our symptoms" because I also have a neuro-immune disorder called Myalgic Encephalomyelitis.

And, of course, I am not a doctor (although I have been known to impersonate one while doing imaginative play with my son)- this is just our story and information that has been helpful or interesting to us. I hope it is helpful and interesting to you!


Thursday, September 25, 2025

Mast Cell Involvement in Other Diseases and Disorders

Mast cell involvement in other diseases and disorders"
In general:
 
 
"Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures."
“Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye?Activated mast cells excrete mitochondrial components, triggering autoimmunity
Children with autism have elevated levels of mast cell mediators in their blood
Mercury causes mast cells to release pro-inflammatory mediators
Is a subtype of autism an allergy of the brain?
Focal Brain Inflammation in Autism
Neuroinflammation and Autism

In the Gut:
Mast Cells in Gastrointestinal Disease
Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside.
Intestinal mast cells in gut inflammation and motility disturbances
Mast Cell Activation in Gallbladder Disease
Mast cell–nerve axis with a focus on the human gut
Mast cells and Cyclic Vomiting Syndrome (also migraine and leaky gut)
Consider Hereditary Angioedema in the Differential Diagnosis for Unexplained Recurring Abdominal Pain
Imatinib and Trigger Avoidance for Mast Cell Activation Syndrome Presenting With Attacks of Abdominal Pain, Nausea, Vomiting, and Diarrhea
Hereditary Angioedema Presenting as Recurrent Acute Pancreatitis
Allergic mastocytic gastroenteritis and colitis: an unexplained etiology in chronic abdominal pain and gastrointestinal dysmotility


In Neurological Conditions:
Mast Cells:  versatile gatekeepers of pain
Mast Cells- the key to Multiple Sclerosis?
Mast Cells, histamine, and Hydroxyzine in MS
Mast cells may lead to abnormal nerve growth such as Neurofibromatosis
Mast cells are involved in the pathogenesis of neurofibromas
Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation
Brain Injury-Mediated Neuroinflammatory Response and Alzheimer's Disease

In the Cardiovascular System and Blood:
Cardiovascular symptoms in patients with systemic mast cell activation disease
Evidence for a Role of Mast Cells in the Evolution to Congestive Heart Failure
"These observations suggest that mast cells play a critical role in the progression of heart failure. Stabilization of mast cells may represent a new approach in the management of heart failure."
The role of mast cells in atherosclerosis

Cardiac mast cells: the centerpiece in adverse myocardial remodeling
Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts
Mast Cells as Effectors in Atherosclerosis
Effects of Primary Mast Cell Disease on Hemostasis and Erythropoiesis
Mast cell activation disorder masquerading as pure red cell aplasia
Polycythemia from mast cell activation syndrome: lessons learned
Mast cell activation syndrome masquerading as agranulocytosis
Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association
Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders