This is a talk given by UK surgeon, Dr James Royle
‘Many of my multidisciplinary team colleagues, fellow surgeons,
oncologists, pathologists, radiologists and specialist nurses all
acknowledged to me sudden change in patterns, and dramatic increase in
these incurable advanced cancers that we’ve observed in these past two
years.’ The close temporal association between the increase cancers and
the rollout fulfills the gold standard Bradford-Hill epidemiological
criteria for causation."
He is making a presentation to medical colleagues focused on colorectal cancers and turns his attention to "turbo cancers", a term he acknowledges as a colloquial one that refers to a phenomenon of rapid onset cancers characterized by their "aggressive biological nature". These cancers are striking people of all ages and are often detected at stage 4 when they are difficult or impossible to treat. In many cases, these are recurrences of cancers that had been successfully treated years prior, and the patient had been cancer-free for many years. These are fast-growing cancers with higher than normal mortality rates and a seemingly different biology- many metastases in cancers where that is normally rare, and cases of synchronous cancers; a previously extremely rare situation in which multiple colon cancers present at the same time in one person. There was a dramatic increase in these cancers in 2021, shortly after the mRNA vaccines for COVID were rolled out.
Some people have suggested that this is a trend that has been happening over a longer period of time, but the rapid increase in these cancers is specific to the time right after the rollout of the mRNA vaccines. It has also been suggested that these are genetic or inherited cancers, and therefore can't be on the rise, citing as evidence the increased expression of genetic mutations in these cancers. The mutations are not known inherited mutations but instead seem to be the spontaneous mutations that occur in cancer cells, and occur more often in aggressive tumors, so the correlation may be the result of causation in the other direction. This is a very important point- aggressive tumor biology, as is seen here, CAUSES more genetic mutations in the tumor cells rather than the opposite situation in which inherited mutations cause the tumor cells.
Recent research has found a link between mRNA vaccination and mechanisms of oncogenesis (the formation of new cancer) and auto-immunity via suppressed immunity. The immune system suppresses cancer formation through mechanisms of surveillance and monitoring, and when those systems are impaired, cancers can more easily form. This principal is not well understood by many people- that cancerous cells happen in our bodies all the time, but in nearly all cases our immune systems destroy them long before they can cause any problems significant enough for their presence to be known. Our bodies are able to clear nearly all cancerous cells; it is actually a very rare event that cancerous cells are able to grow into what most of us think of as "cancer" that shows up on tests and can threaten our health. Others have suggested that the sudden increase in colorectal "turbo cancers" is due to processed food in the diet, obesity, and a sedentary lifestyle, but he points out that these things were present before the sudden change in prevalence and biology of the "turbo cancers".
Another proposed theory is "stage migration"- that the lockdowns are responsible because they led to suspended cancer screenings and delayed diagnoses. He says that in the UK they actually only suspend screenings briefly and they treated more, not fewer, patients because colorectal cancer was one type that they could work with despite the restrictions. In the UK, cancer screenings usually begin at age 60 and the dramatic increases in cancers are mostly in younger people who wouldn't have been screened anyways.
The timing of the turbo cancers becoming suddenly prevalent immediately following the rollout of the vaccine supports a connection but is not proof itself. There are at least 12 different proposed mechanisms with evidence to support them that could explain how the mRNA vaccines could "produce, potentiate, or accelerate" cancers, including t-cell exhaustion, "unacceptably high levels of bacterial plasmid contamination", and the presence of the SV40 tumor promoter. These mechanisms have been discussed by many respected researchers and doctors (references below).
"The shots are clearly causing generalized immunosuppression" and the immune system plays an extremely important role in monitoring for mutated cells that may become cancerous and removing them before significant disease can occur. Dr Royle reports having submitted multiple "yellow cards" (the UK system for monitoring vaccine adverse events) but that none of his reports were followed up on, and he says that other clinicians are reporting similar experiences. Dr Royle further reports that he was told by many of his colleagues that he was "brave" for speaking publicly about the concerns he has about the safety of the COVID mRNA vaccines, and that many of these colleagues told him they agree with him but are afraid to speak publicly for fear of retaliation.
MORE EVIDENCE:
The pseudo-uridine in the spike RNA was created and included to replace the normal uridine because the spike protein with the normal uridine was being broken down "too quickly" (at the normal rate) and they wanted to prolong the amount of time that the artificially created spike protein would be present in the body. The reason they gave for not doing studies on how it would affect the breakdown of the artificially-created spike protein was that they assumed that it wouldn't impact how it was broken down. Clearly this is a contradiction. Eventual studies show that it takes about half a year for the spike with the pseudo-uridine to break down and leave the body. There has been a trend of increasing diagnosis of late-stage cancers in young people, many of whom have no family history or other known risk factors for the cancers. Some of the doctors raising the alarm are some of the most prominent and published in their respective fields, including Peter McCullough MD, MPH one of the most published cardiologists in the world; Paul Marik, MD who is the second-most published ICU doctor in the world; Robert Malone, MD who is one of the inventors of mRNA vaccine technology.
Interview with Dr William Makis (an oncologist from Canada)
Turbo cancers are aggressive cancers that are arising in COVID-vaccinated individuals, particularly in young people. Dr Makis says he has diagnosed approximately 20,000 cancers in his career and has never before seen cancers behaving the way these turbo cancers are. They present at a late stage and they grow very rapidly. He explains that they present at a late stage, stage 3 or 4, because they grow so fast and aren't producing symptoms earlier. For example there are now many cases of stage 3 or stage 4 breast cancer in women in their 20s and early 30s. Another example are colon cancers appearing in people in their 20s and 30s- which has previously been very rare (there is a reason that colon cancer screenings don't begin until age 40-60). Their growth is so rapid that when tumors are surgically removed, it is found that they have spread even though before the surgery there weren't signs that they had already spread.
These cancers are occurring in people younger than they normally do, and this means that sometimes people that young aren't looking out for symptoms of cancer, or are less concerned about having aches and pains. The evidence for this comes from many areas, but they show some of the massive numbers of "go fund me" pages for young people with late stage cancer, and it makes an impression. They also point out that there does seem to be a higher incidence of these turbo cancers in teachers and nurses, people who got vaccinated early as "essential workers". When asked about whether this is just anecdotal, Dr Makis responds that he first noticed the trend when looking into the rise of sudden deaths in Canadian doctors, who had had mandates for COVID vaccination. He also noticed the increase in aggressive, late-stage cancers in this group.
The first potential mechanism that Dr Makis discusses is the issue of the pseudo-uridine that was introduced into the mRNA. He says it seems to dampen the immune system by affecting the toll-like receptors. This has downstream effects that haven't been well-studied, but one seems to be that the cancer surveillance systems are suppressed. There are several ways that the vaccines seem to be altering the signaling of immune cells, including t-cells. Other possible mechanisms include the risk that the mRNA is being integrated into our genomes by reverse-transcription, and DNA contamination has been discovered in the Pfizer and Moderna vials.
(at 11:44) According to Dr. Phillip Buckhaults, PhD, who is a molecular biologist who studies cancer genomics (and who describes himself as an expert on the many ways that environmental factors can alter our genetic code, and whether those alterations can cause cancer), the fact that the Pfizer vaccine is contaminated with plasmid DNA could be causing health problems in people and is a sign that something is seriously wrong with the regulatory process that allowed this to happen. This plasmid DNA was used as the template for in vitro transcription as part of the manufacturing process of the vaccine (plasmid DNA are small rings of DNA). It is much easier for DNA to become integrated into our genome than it is RNA. This DNA could be responsible for the increase in cardiac arrests, could lead to autoimmunity towards tissues, and could lead to the development of cancer depending on where the DNA gets integrated into the DNA- it could interrupt a tumor-suppressor gene or activate an oncogene. This is a hazard for genome modification for long lived somatic cells such as stem cells. Dr Buckhaults was able to directly study the contents of the vaccine vials given out at the university where he works because the person in charge of that program saved all of the vials used, and those vials contained a residue of their former contents.
Kevin McKernon, former team leader of R and D on the Human Genome Project at MIT, reported that as much as 30% of the genetic material in the vaccine vials was plasmid DNA, representing a very high amount of contamination. This DNA could also be picked up by our gut bacteria, or other bacteria in our bodies, and then these bacteria could theoretically be producing spike protein. It is a good time for a reminder that spike protein is highly toxic to our bodies. Several other factors here are the lipid nano particles, and the fact that we were all assured that the vaccine dose would remain locally in the arm where we now know that it is distributed systemically. Dr McKernon has also found SV40 contamination in the DNA plasmids- this is an oncogenic virus.
Another possible mechanism of cancer causation is the IgG4 antibody shift that has been observed. Repeated exposure to antigens can increase IgG3 antibodies, which are antibodies of tolerance. It is our body's way of saying that since we are repeatedly being exposed to something it is NOT a threat. In this way, boosters can be acting as "allergy shots" rather than vaccines. You begin to produce the IgG4 once you've had the second injection, but once you have a third- a booster- the levels go up by 500%. Your body then stops producing IgG1 and IgG3, which are the antibodies that respond to viral infection, but they are also the antibodies responsible for cancer surveillance.
These turbo cancers seem to be increasing in prevalence. Standard treatments don't work and there are no new or specific treatments for these cancers. Dr Makis reports being locked out of his office, and others trying to raise concern about the COVID vaccines as well. His substack is makismd.substack.com
Studies referenced in the video:
Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report
"Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL."
Bell’s palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature
"The malignancy was of cutaneous origin and the case showed symptoms consistent with Bell's palsy and trigeminal neuralgia beginning four days post-vaccination (right side head temporal pain). The temporal pain was suggestive for inflammation and impairment of T cell immune activation... In this study we describe all aspects of this case and discuss possible causal links between the rapid emergence of this metastatic cancer and mRNA vaccination. We place this within the context of multiple immune impairments potentially related to the mRNA injections that would be expected to potentiate more aggressive presentation and progression of cancer. The type of malignancy we describe suggests a population risk for occurrence of a large variety of relatively common basaloid phenotype cancer cells, which may have the potential for metastatic disease. This can be avoidable with early diagnosis and adequate treatment. Since facial paralysis/pain is one of the more common adverse neurological events following mRNA injection, careful inspection of cutaneous/soft tissue should be conducted to rule out malignancy. An extensive literature review is carried out, in order to elucidate the toxicity of mRNA vaccination that may have led to the death of this patient."
IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein
"As the immunity provided by these vaccines rapidly wanes, their ability to prevent hospitalization and severe disease in individuals with comorbidities has recently been questioned, and increasing evidence has shown that, as with many other vaccines, they do not produce sterilizing immunity, allowing people to suffer frequent re-infections. Additionally, recent investigations have found abnormally high levels of IgG4 in people who were administered two or more injections of the mRNA vaccines."
Significantly, this paper outlines 6 potential ways that the IgG4 class-switching of antibodies could have negative unintended consequences for the host individual:
"We propose a hypothetical immune tolerance mechanism induced by mRNA vaccines, which could have at least six negative unintended consequences:
(1) By ignoring the spike protein synthesized as a consequence of vaccination, the host immune system may become vulnerable to re-infection with the new Omicron subvariants, allowing for free replication of the virus once a re-infection takes place. In this situation, we suggest that even these less pathogenic Omicron subvariants could cause significant harm and even death in individuals with comorbidities and immuno-compromised conditions.
(2) mRNA and inactivated vaccines temporally impair interferon signaling [142,143], possibly causing immune suppression and leaving the individual in a vulnerable situation against any other pathogen. In addition, this immune suppression could allow the re-activation of latent viral, bacterial, or fungal infections and might also allow the uncontrolled growth of cancer cells [144].
(3) A tolerant immune system might allow SARS-CoV-2 persistence in the host and promote the establishment of a chronic infection, similar to that generated by the hepatitis B virus (HBV), the human immune deficiency virus (HIV), and the hepatitis C virus (HCV) [145].
(4) The combined immune suppression (produced by SARS-CoV-2 infection [15,16,17,18,19,20,21,22] and further enhanced by vaccination [142,143,144]) could explain a plethora of autoimmune conditions, such as cancers, re-infections, and deaths temporally associated with both. It is conceivable that the excess deaths reported in several highly COVID-19-vaccinated countries may be explained, in part, by this combined immunosuppressive effect.
(5) Repeated vaccination could also lead to auto-immunity: in 2009, the results of an important study went largely unnoticed. Researchers discovered that in mice that are otherwise not susceptible to spontaneous autoimmune disorders, repeated administration of the antigen promotes systemic autoimmunity. The development of CD4+ T cells that can induce autoantibodies (autoantibody-inducing CD4+ T cells, or aiCD4+ T cells), which had their T cell receptors (TCR) modified, was triggered by excessive stimulation of CD4+ T cells. The aiCD4+ T cell was generated by new genetic TCR modification rather than a cross-reaction. The excessively stimulated CD8+ T cells induced them to develop into cytotoxic T lymphocytes (CTL) that are specific for an antigen. These CTLs were able to mature further by antigen cross-presentation, so in that situation, they induced autoimmune tissue damage resembling systemic lupus erythematosus (SLE) [146]. According to the self-organized criticality theory, when the immune system of the host is continually overstimulated by antigen exposure at concentrations higher than the immune system’s self-organized criticality can tolerate, systemic autoimmunity inevitably occurs [147].
It has been proposed that the amount and duration of the spike protein produced are presumably affected by the higher mRNA concentrations in the mRNA-1273 vaccine (100 µg) compared to the BNT162b2 vaccine (30 µg) [31]. Thus, it is probable that the spike protein produced in response to mRNA vaccination is too high and lasts too long in the body. That could overwhelm the capacity of the immune system, leading to autoimmunity [146,147]. Indeed, several investigations have found that COVID-19 immunization is associated with the development of autoimmune responses [148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166].
(6) Increased IgG4 levels induced by repeated vaccination could lead to autoimmune myocarditis; it has been suggested that IgG4 antibodies can also cause an autoimmune reaction by impeding the immune system’s ability to be suppressed by regulatory T cells [102]. Patients using immune checkpoint inhibitors alone or in combination have been linked to occurrences of acute myocarditis [103,104,105,106,107], sometimes with lethal consequences [102]. As anti-PD-1 antibodies are class IgG4, and these antibodies are also induced by repeated vaccination, it is plausible to suggest that excessive vaccination could be associated with the occurrence of an increased number of myocarditis cases and sudden cardiac deaths.
Finally, these negative outcomes are not expected to affect all people who have received these mRNA vaccines. Individuals with genetic susceptibility, immune deficiencies, and comorbidities are probably the most likely to be affected. However, this gives rise to a disturbing paradox—if people who are the most affected by the COVID-19 disease (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them? As Omicron subvariants have been demonstrated to be less pathogenic [133,134,135,136,137], and mRNA vaccines do not protect against re-infection [14,138], clinicians should be aware of the possible detrimental effects on the immune system by administering boosters."
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
"Shortly after the initial two mRNA vaccine doses, the immunoglobulin G (IgG) response mainly consists of the proinflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of noninflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose, on average, from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination."
Appearance of tolerance-induction and non-inflammatory SARS-CoV-2 spike-specific IgG4 antibodies after COVID-19 booster vaccinations
"Findings demonstrate robust IgG responses after primary Covishield or mRNA doses; declining to baseline within six months. First mRNA booster restored and surpassed primary IgG responses but waned after six months. Surprisingly, a second mRNA booster did not increase IgG levels further. Comprehensive IgG subclass analysis showed primary Covishield/mRNA vaccination generated predominantly IgG1 responses with limited IgG2/IgG3, Remarkably, IgG4 responses exhibited a distinct pattern. IgG4 remained undetectable initially but increased extensively six months after the second mRNA dose, eventually replacing IgG1 after the 3rd/4th mRNA doses. Conversely, initial Covishield recipients lack IgG4, surged post-second mRNA booster. Notably, mRNA-vaccinated individuals displayed earlier, robust IgG4 levels post first mRNA booster versus Covishield counterparts. IgG1 to IgG4 ratios decreased with increasing doses, most pronounced with four mRNA doses. This study highlights IgG response kinetics, influenced by vaccine type and doses, impacting immunological tolerance and IgG4 induction, shaping future vaccination strategies."
The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines
"The seropositivity of anti-RBD IgG4 after the vaccination was 6.76% at 1 month after the second dose, gradually increased to 50.5% at 6 months after the second dose, and reached 97.2% at 1 month after the third dose. The seropositivity and titers of anti-RBD IgG1/IgG3 quickly reached the maximum at 1 month after the second dose and declined afterward. The elevated anti-RBD IgG4 Ab levels observed after repeated vaccinations were unlikely to increase the risk of breakthrough infection."
Mechanisms and implications of IgG4 responses to SARS-CoV-2 and other repeatedly administered vaccines
"Vaccine-induced immunoglobulin G (IgG) profiles can vary with respect to the predominant subclasses that characterize the response. Among IgG subclasses, IgG4 is reported to have anti-inflammatory properties, but can also exhibit reduced capacity for virus neutralization and activation of Fc-dependent effector functions... The clinical implications of vaccine-induced IgG4 responses remain uncertain, though collective evidence suggests that proportional increases in IgG4 might reduce vaccine antigen-specific immunity. Additional work is needed to determine underlying mechanisms and to elucidate what role IgG4 may play in modifications of vaccine-induced immunity to disease."
A case of IgG4-related ophthalmic disease after SARS-CoV-2 vaccination: case report and literature review
"A variety of autoimmune diseases occur after SARS-CoV-2 infection or vaccination, of which IgG4-related disease (IgG4-RD) is an important type. IgG4-RD can involve multiple organs of the body. The ocular manifestation of IgG4-RD is called IgG4-related ophthalmic disease (IgG4-ROD). We herein report a patient diagnosed with IgG4-ROD. The patient developed ptosis and vision loss after SARS-CoV-2 vaccination, and the symptoms worsened after SARS-CoV-2 infection. After excluding other diseases like myasthenia gravis and Eaton-Lambert syndrome that may cause ptosis, the diagnosis of IgG4-ROD was confirmed by pathological examination."
Immunoglobulin G4-Related Disease Manifesting as Isolated, Typical, and Nontypical Gastroesophageal Lesion: A Research of Literature Review
" Immunoglobulin G4-related disease (IgG4-RD) is an autoimmune inflammatory and fibrotic condition. The disease is characterized by tissue infiltration with dense lymphoplasmacytes and IgG4-positive plasma cells... The majority of lesions were inflammatory tumors, ulceration, nodular lesions, chronic gastritis, and malignant lesions. Key Messages: IgG4-RD may be manifested by isolated, typical and nontypical forms of gastroesophageal lesions and should be taken into consideration in the differential diagnosis. Corticosteroids may be the sole diagnostic treatment for this condition."
A rare case of IgG4-associated disease caused by COVID-19: Case report and literature review
"An increasing number of cases have reported that coronavirus disease 2019 (COVID-19) can lead to immune system dysregulation and induce autoimmune diseases, but the mechanism is unclear. We treated a patient who presented with an unknown fever after infection with the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2023. After excluding the possibility of infection, malignancy, and other connective tissue diseases, we considered the diagnosis of IgG4-related disease in consideration of the patient's pathology and clinical findings. In this article, we summarize our diagnostic experience and summarize the case reports of IgG4-related diseases associated with SARS-CoV-2 infections since the COVID-19 pandemic."
