This blog is a way of sharing the information and resources that have helped me to recover my son Roo from an Autism Spectrum Disorder. What I have learned is to view our symptoms as the results of underlying biological cause, which can be identified and healed. I say "our symptoms" because I also have a neuro-immune disorder called Myalgic Encephalomyelitis.

And, of course, I am not a doctor (although I have been known to impersonate one while doing imaginative play with my son)- this is just our story and information that has been helpful or interesting to us. I hope it is helpful and interesting to you!


Showing posts with label cancer. Show all posts
Showing posts with label cancer. Show all posts

Wednesday, March 12, 2025

Mold-Induced Illness

(work in progress)

Significant exposure to mold and related organisms, usually prolonged, can cause a wide range of symptoms and conditions.  This is a common cause or exacerbating factor for MCAS.  Common symptoms of mold illness include fatigue, headaches, digestive problems, respiratory problems (including asthma and shortness-of-breath), cough, sore throat, allergies and reactions that look like allergies (such as sneezing, hives, rashes), excessive thirst, muscle cramps, joint pain, stiffness in the morning, sleep problems, night sweats, brain fog and related cognitive issues (such as problems with memory and executive function), light sensitivity, blurred vision,  numbness, tingling, and tremors.

Mold illness can be diagnosed as many things, including- ME/CFS, Fibromyalgia, MS, Somatization disorders, anxiety, depression, PTSD, ADHD, dementia, Irritable Bowel Syndrome, and more.  That is to say that you may meet criteria for one or more of these diagnoses, but mold exposure is the reason that you have the symptoms in the first place.  For some people, treating and healing from the mold illness allows them to heal and lose the diagnosis.  Whether or not they "actually had" the illness then becomes a semantic issue rather than a scientific one.

The Basics of Mold Illness and Toxicity
Mold Toxicity - Depression, Anxiety, Fatigue, Brain Fog & Inattention 
Mold "can contribute to Pyrrole Disorder due the stress it puts on the body.  It can lead to elevated copper by overwhelming one of the antioxidants in the body that regulates copper.  Because it interferes with the immune system, it can lead to a susceptibility to candida/yeast, Lyme and its co-infections.  It also frequently worsens mast cell activation."

Mold can thrive in water damaged buildings or anywhere indoors where there is retained moisture, including AC units and ductwork.  The mold thrives because it has the ideal conditions for growth and because it doesn't have the competition that keeps it in check outdoors.  Additionally, mold spores and toxins build up inside without the natural ventilation that exists outside.  Mold can poison us with toxins and it can also colonize our bodies, such as our sinuses and GI tract.  Some people also have mold allergy.

"Seemingly 25% of people are unable to make antibodies to mold toxins. Add to that the 50% of buildings that have water damage, and you have a lot of people who are unknowingly becoming toxic while spending time in affected homes, schools, workplaces, cars, dorms, and nurseries."

"Mold toxins basically go from the body, to the liver and gallbladder where they are bound to bile and sent out into the gastrointestinal tract. The bile, however, is recycled (as a means of conservation), and thus take toxins back into the body."  

Some of the symptoms that she lists that I don't see listed often include: electric shock sensations, ice-pick pains, Atypical Parkinson's Disease, Atypical ALS, Psychogenic seizures or pseudo-seizures​​, Tics, spasms and seizure like events; Sensitivity to light touch, Suspected or Diagnosed PANS/Pediatric Acute-Onset Neuropsychiatric Syndrome, Rapid weight gain, Body temperature dysregulation, and diagnosis of fibromyalgia, or chronic fatigue.  
Detection of Mycotoxins in Patients with Chronic Fatigue Syndrome
"Urine specimens from 104 of 112 patients (93%) were positive for at least one mycotoxin (one in the equivocal range). Almost 30% of the cases had more than one mycotoxin present. OTA was the most prevalent mycotoxin detected (83%) with MT as the next most common (44%). Exposure histories indicated current and/or past exposure to WDB in over 90% of cases. Environmental testing was performed in the WDB from a subset of these patients. This testing revealed the presence of potentially mycotoxin producing mold species and mycotoxins in the environment of the WDB. Prior testing in a healthy control population with no history of exposure to a WDB or moldy environment (n = 55) by the same laboratory, utilizing the same methods, revealed no positive cases at the limits of detection."

Most doctors who specialize in mold illness use urinary mycotoxin testing to figure out which mycotoxins a patient is dealing with, as treatment consists largely of the use of binders and different ones bind different toxins  

Comprehensive Guide to Mycotoxin Binders

MCAS & Mold: Fungal Colonization of the Sinuses (video)

Mold often co-occurs with other organisms, such as bacteria, in water-damaged buildings.
Aerobic Actinomycetes of Clinical Significance

CIRS (Chronic Inflammatory Response Syndrome)
There is another condition called CIRS (Chronic Inflammatory Response Syndrome) which seems to me to be essentially another name for MCAS, but was recognized and described without as thorough an understanding of the underlying immunological mechanisms.  CIRS-WDB refers specifically to the condition when developed after prolonged exposure to the inside of water-damaged buildings.  According to this 2024 study, CIRS is "an acquired medical condition characterized by innate immune dysregulation following respiratory exposure to water-damaged buildings (WDB).", and states that ME/CFS is "a common misdiagnosis of CIRS".  MedicineNet gives a more detailed description of CIRS "a multisystem and multi-symptom illness that occurs when a person gets exposed to toxins such as mold spores or biotoxins found in tick or spider bites. These toxins get attached to the immune system to trigger an inflammatory response and induce hormonal changes. The immune system produces an excess of cytokines that can lead to the immune system attacking its tissues, causing inflammation and other associated symptoms."  This source further defines biotoxins as "fat-soluble molecules that travel from cell to cell without entering the bloodstream" and further states that "measuring biotoxins in the blood is difficult, but doctors usually identify them by the damage inflicted on various organs."

According to Dr Shoemaker, there are some HLA-DR/DQ haplotypes (combinations of genes that are inherited together) that make a person less able to clear biotoxins, such as mold toxins, from their bodies, making them more likely to develop CIRS when exposed to mold, which then cause the innate immune system to overreact and lead to chronic inflammation.  These include:
HLA-DR4-3-53
HLA-DR7-2/3-53
HLA-DR11-3-52B
HLA-DR13-6-52A/B/C
HLA-DR17-2-52B
HLA-DR18-4-52A

Diagnostic Process for Chronic Inflammatory Response Syndrome (CIRS): A Consensus Statement
Report of the Consensus Committee of Surviving Mold
"Clinical management of patients with a complex, multisystem, multi-symptom illness identified as a chronic inflammatory response syndrome (CIRS) has expanded. Often associated with illness due to exposure to low molecular weight biotoxins and inflammagens found (i) inside water-damaged buildings (WDB); (ii) following exposure to blooms of cyanobacteria; (iii) following consumption of ciguatoxic fish; and (iv) following confirmed acute Lyme disease, persistent despite reasonable use of antibiotics, CIRS is increasingly recognized. A need for a formal case definition and case management protocol has arisen. Patients with CIRS will have abnormalities in innate responses, reduced levels of
regulatory neuropeptides MSH and VIP, elevated inflammatory markers of C4a, MMP9 and TGF beta-1.  Systemic illness, based on abnormal gene activation and suppression, as shown by RNA Seq and transcriptomics, requires a multi-factorial, rigorous diagnostic assessment to assist in both differential diagnosis and monitoring response to therapy. A consensus statement is herein provided to assist practitioners in case identification and management."

Chronic inflammatory response syndrome: a review of the evidence of clinical efficacy of treatment

Dr. Scott McMahon, a board-certified pediatrician and CIRS specialist (Podcast)


Treatment for Mold Illness
The Shoemaker Protocol is widely recognized as the best treatment for mold-induced illness, whether or not you call it CIRS.  

Doctors who specialize in treating people with mold-induced illness tend to use urinary mycotoxin testing to identify which mycotoxins a person is dealing with, and prescribe substances that bind and remove those specific toxins as part of the treatment protocol.  Examples of binders include bentonite clay, activated charcoal, chlorella, cholestyramine, and colesevelam HCI. 

Finding and Remediating Mold in Your Environment
Consensus Statement for Microbial Remediation 2020
(Indoor Environmental Professional Panel of Surviving Mold)

Dr Jill Carnahan is considered by many to be an authority on cleaning mold and mold remediation.  This page from her website has the basics:
How to Get Rid of Mold – Definitive Mold Removal Guide

"Michael Rubino provides valuable resources and professional guidance on safely addressing mold issues in your home. His website offers detailed information on proper mold cleaning techniques, prevention, and the importance of air quality in maintaining a healthy living environment."

This is information given to me by someone with specialized knowledge of building materials:
"MDF is Medium-Density Fiberboard. There is also OSB, or Oriented Strand Board, and there are number of other building products like particle board made with the tailings or trash from milling lumber, held together by resins. The wood millings are damp from cutting, lay around in damp piles, and develop mold. The mold in this wood is fed by the resins used to make it into building materials. The paper backing on drywall has the same issue. I understand that there is now third-party certified mold-free OSB and MDF made differently."

ImmunoLytics swab tests

Resources Regarding Mold and Mold Illness:
Dr Ritchie Shoemaker's "Surviving Mold" website

International Society For Environmentally Acquired Illnesses / ISEAI website

American Academy for Environmental Medicine 
(database of practitioners who treat environmentally acquired illnesses including mold)

Dr Neil Nathan, MD is an expert in mold illness.  This book from him is highly regarded:
Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness

Dr Jill Crista, ND is a highly respected mold doctor.  "Dr. Jill focuses on conditions that cause injury to the brain and nervous system, including mold, PANS/PANDAS, Lyme disease, and concussion."
Dr Jill Crista online courses about mold 

Dr. Efrat Lamandre focuses on integrative and functional medicine, offering solutions for mold toxicity, chronic illnesses, and environmental health issues. Her practice emphasizes a holistic approach to diagnosing and treating mold-related conditions. Her website provides information and support for those navigating mold toxicity and other environmental health concerns.
Toxic Overload and Chronic Illness
: How Mold, Plastics and Pesticides Make You Sick

#moldfinders: RADIO (Podcast)
Mold expert Brian Karr shares his secrets on how to find and remove mold and mycotoxins from your home,

The Virginia Center for Health and Wellness (has video series from Dr Andrew Heyman 

National Institute of Environmental Health Sciences Mold Information

CDC Information About Mold 

EPA Information About Mold

RealTime Laboratories, Inc. (RTL)
"RealTime Laboratories, Inc. (RTL) is a CAP and CLIA accredited clinical and environmental diagnostic laboratory that specializes in testing for and identifying hazardous mold, toxins, and infectious diseases."  They have a free e-book called:
Mycotoxins 101: An Introduction to Crucial Facts

MyMycoLab provides mycotoxin testing

Mold prevention strategies and possible health effects in the aftermath of hurricanes and major floods

The Hidden Connection: COVID, Mold Exposure, and Viral Reactivation 

A comprehensive review of mold research literature from 2011 - 2018



Legal Resources
Well.Law is a legal practice that understands the complexities of mold-related and environmental illness cases. They support clients navigating housing issues, disability rights, and toxic exposure with compassion and legal expertise. She started the personal injury firm she couldn't find.

How to get the most insurance money for mold remediation
"Learn the secrets insurance companies don’t want you to know that will maximize your insurance coverage amount."

Mold Insurance Playbook with Corey Levy (Podcast)
"It can be really expensive... But what if you didn’t have to pay full price for remediation? That’d be awesome! Today we share our entire playbook on how to maximize your coverage! Here is the quick overview... and we go in depth on each one of these in the episode: 1) DON’T CALL YOUR INSURANCE COMPANY! 2) STOP the water 3) Mold Inspection 4) Get Remediation Bids 5) Hire a public adjuster 6) Now you can contact your insurance company... If you go out of order you can literally cost yourselves tens of 1,000s of dollars!"


Thursday, September 7, 2023

Some Antihistamines Found to Treat Cancer

Researcher Aims to Hinder Allergic Responses, Keep Cancer Cells from Dividing
Dr. Glenn Cruse, an associate professor of immunology at the NC State College of Veterinary Medicine, researches "the molecular mechanisms — including genes and proteins — that control mast cell function, with the hope of developing ways to prevent mast cells from being activated. His research also aims to develop therapeutics for cancer by inhibiting the KIT growth factor receptor in mast cells."  His team is currently studying "the MS4A gene family that have been associated with asthma susceptibility."  His team has already found a way to induce the cell to make a defective version of a subunit of the receptor, called MS4A2, which doesn't trigger the inflammatory response when IgE is bound to it.  These findings show potential for becoming a treatment for asthma, but the team also discovered that in humans there is another, related protein that partially compensates for the defective one, meaning a treatment in humans must be more complex.

"We previously found an exon-skipping oligonucleotide, which we have termed KitStop, that safely reduces the severity and duration of the anaphylactic response by depopulating mast cells in tissues. We target a growth factor receptor called KIT that’s critical for mast cell survival and force it to produce a different version of that mRNA code for a protein. By doing that, we make the protein and growth factor receptor nonfunctional, essentially causing mast cells to die." This might prove to be an effective treatment for mast cell cancers and mast cell leukemia, as well as forms of mastocytosis that involve invasion of the tissues by mast cells, by being able to selectively kill the mast cells. 

Desloratadine and loratadine stand out among common H1-antihistamines for association with improved breast cancer survival
"As tumors maintain an inflammatory microenvironment, anti-inflammatory medication can be useful in cancer therapy. We have previously shown an association with improved survival in melanoma for use of the H1-antihistamines desloratadine and loratadine, and here we examine use of H1-antihistamines and breast cancer mortality.  We investigated use of the six major H1-antihistamines (cetirizine, clemastine, desloratadine, ebastine, fexofenadine and loratadine) and breast cancer-specific and overall mortality in a nation-wide register-based study of all 61,627 Swedish women diagnosed with breast cancer 2006–2013.  

We found a consistently improved survival of desloratadine users, as well as of loratadine users, relative to nonusers, regardless of patient age, menopause, estrogen receptor status or stage of the tumor, or whether breast cancer-specific or overall survival was analyzed. The survival of users of other antihistamines varied relative to non-users.

Based on their safety and current use within the patient population, together with our observations, we suggest the initiation of trials of desloratadine and loratadine as treatment of breast cancer as well as studies of the mechanism behind their possible effect. Further studies on any effects of other H1-antihistamines may also be merited, as well as of H1-antihistamine use and survival in other malignancies."

Histamine receptor 1 inhibition enhances antitumor therapeutic responses through extracellular signal-regulated kinase (ERK) activation in breast cancer

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment
"Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for cytotoxicity against NSCLC cells and identified several CAD antihistamines as inducers of lysosomal cell death. We then performed a cohort study on the effect of CAD antihistamine use on mortality of patients diagnosed with non-localized cancer in Denmark between 1995 and 2011. The use of the most commonly prescribed CAD antihistamine, loratadine, was associated with significantly reduced all-cause mortality among patients with non-localized NSCLC or any non-localized cancer when compared with use of non-CAD antihistamines and adjusted for potential confounders. Of the less frequently described CAD antihistamines, astemizole showed a similar significant association with reduced mortality as loratadine among patients with any non-localized cancer, and ebastine use showed a similar tendency."

H1-Antihistamines Reduce the Risk of Hepatocellular Carcinoma in Patients With Hepatitis B Virus, Hepatitis C Virus, or Dual Hepatitis B Virus-Hepatitis C Virus Infection
"AH use may reduce the risk for HCC among patients with HBV, HCV, or dual infection in a dose-dependent manner. Further mechanistic research is needed."

Sunday, June 12, 2022

New and Unconventional Cancer Treatments

BURZYNSKI: THE CANCER CURE COVER-UP - FULL DOCUMENTARY
Suppressing a cure for more than 40 years.

This Revolutionary Treatment Kills Cancer From the Inside Out

Edmond man says cheap drug for dogs cured his cancer

Finally, some good news about cancer | Jimmy Lin | TEDxBaltimore

How Nature Has Already Beat Cancer | Carlo Maley

A "living drug" that could change the way we treat cancer 

Naltrexone at low doses (LDN) and its relevance to cancer therapy

"We review three mechanisms through which LDN can influence cancer progression; namely, (a) antagonism of receptors to which LDN binds, which include toll-like receptors 7–9 that lead to IL-6 suppression b) modulation of immune function in patients; and c) direct inhibition of signaling pathways involved in cancer cell control, including the priming of pro-apoptotic pathways.

Considering the increase in the number of anecdotal reports of activity, there will likely be a bigger drive toward using LDN in the oncological setting. These reports support clinical trials of LDN in cancer, especially when given in combination with certain chemotherapy."

Using sound waves to destroy cancer | Christine Gibbons | TEDxDetroit
A new treatment for cancer is presented here, called Histotripsy, which uses sound energy delivered by ultrasound to destroy cancerous tumors.  Using sound to create heat to kill tumors has been tried, but this is a new approach that actually uses the sound to create mechanical forces.  These mechanical forces are more precise than heat and lead to less pain and faster recovery.  This concept is illustrated at 3:38  

Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege

The Rife Machine
In 1938, Dr Royal Raymond Rife invented a machine that can produce the resonant frequency of a cancer or pathogen, meaning it can find the frequency of that entity and then magnify the sound waves until it tears apart the entity.  He cured 16 terminally ill cancer patients.  Other researchers were able to significantly reduce the number of malignant cells in leukemia.  This is the same force that explains why wine glasses will shatter if someone sings a certain note very loudly near them.  Anthony Holland, a musician, began studying Rife's work, calling it Novobiotronics.  In October 2013, he published a scientific paper showing significant improvements in cancer and antibiotic resistant bacteria.  Additional research, done in 2011 by Peter Jurdiaf, used sound and light frequencies to modify and reprogram DNA.  His research successfully changed frog embryos to salamander embryos.  It is currently believed by many that around 97% of the DNA in human cells is useless and is referred to as "junk DNA". 

Tuesday, February 22, 2022

Breakthroughs in Treating Cancer

New drug for colo-rectal cancer has 100% success in clinical trial
Dr Andrea Cercek, from Sloan Kettering Cancer Center, discusses a recent small drug trial in which 14 test subjects with advanced colo-rectal cancer were given a new med called dostarlimab and all 14 went into remission.  Dr Cercek says it was as if the tumors just vanished and the treatment had very low toxicity.  The drug helps because it repairs a genetic condition in many of these cancer cells in which they lack the gene for an enzyme that repairs damaged DNA.  It basically enables the immune system to recognize and fight the cancer.  The therapy takes about 6 months.  There is hope that this therapy can be used in other similar cancers (in which the body lacks the needed enzyme) such as stomach, bladder, and pancreatic cancer.  

Tiny Shape-Shifting Microrobots Can Locate Cancer Cells. With Magnets?
"Today, most patients enrolled in chemotherapy treatment receive cancer-killing drugs either orally or intravenously. But both methods come with undesirable side effects. The new method could reduce these, and also lend new applications to 3D-printed robotic animals. Such tiny creatures are guided to their goal (in this case, cancer cells) via magnets, and release the drug payload once they enter the acidic environment immediately surrounding the tumor."
For more on this see this article.

Princeton team disables long-targeted gene behind spread of major cancers
"This discovery has its roots in 2004 research in which Princeton scientists identified a gene implicated in metastatic breast cancer, called metadherin, or MTDH. A 2009 paper by cancer biologist Yibin Kang then showed the gene was amplified and produced abnormally high levels of MTDH proteins in around a third of breast cancer tumors, and was central to not just the process of metastasis, but also the resistance of those tumors to chemotherapy."

"Subsequent research continued to shed light on the importance of the MTDH gene, demonstrating how it is critical for cancer to flourish and metastasize. Mice engineered to lack the gene grew normally, and those that did get breast cancer featured far fewer tumors – and those tumors that did form didn't metastasize. This was then found to be true of prostate cancer, lung cancer, colorectal cancer, liver cancer and many other cancers."

“In the two papers we are publishing back-to-back today, we identify a compound, show it is effective against cancer, and show that it is very, very effective when combined with chemotherapy and immunotherapy,” says Kang. “Even though metastatic cancers are scary, by figuring out how they work – figuring out their dependency on certain key pathways like MTDH – we can attack them and make them susceptible to treatment.” 

Using sound waves to destroy cancer | Christine Gibbons | TEDxDetroit
A new treatment for cancer is presented here, called Histotripsy, which uses sound energy delivered by ultrasound to destroy cancerous tumors.  Using sound to create heat to kill tumors has been tried, but this is a new approach that actually uses the sound to create mechanical forces.  These mechanical forces are more precise than heat and lead to less pain and faster recovery.  This concept is illustrated at 3:38 

Thursday, January 28, 2016

Environmental Toxicity

This is a huge topic and will be the focus of a number of posts, but for now I want to get some of these resources up for people who are asking for them.  So often people allude to "environmental toxicity" as a cause or contributor to disease, but what do they mean by that?  What exactly are these toxins, where do our exposures to them come from, and what do we know about them?  People sometimes question whether there is science behind these fears, while others become frustrated with how pervasive the problem is and throw up their hands in defeat, saying that there is simply too much for us to avoid so why even try.  For those of us who know we have been harmed by some of these toxins it can be painful to find out just how much was known, how early, and yet we were still allowed to be harmed.  Yes, there has been some "better living through chemistry" (which comes from a marketing slogan from DuPont when it was trying to save it's destroyed public image back in the 1930s), but this progress has been reckless and has ended and destroyed many, many lives, and those lives matter too.

The cost of a polluted environment: 1.7 million child deaths a year, says WHO.

For my post about environmental sources of metals, go here.  This post focuses on other toxins mostly.

GENERAL SOURCES FOR INFORMATION:
TOXNET is part of the NIH National Library of Medicine and is an incredible resource.  It contains links to many databases with various toxicology information, such as the Hazardous Substances Data Bank, which has peer-reviewed toxicology info for over 5,000 toxic chemicals, another one with over 4 million literature references regarding the toxicity and effects of drugs and toxic chemicals, another with interactive maps health data and EPA data such as superfund sites, even databases of info about the effects of drugs on lactating and pregnant women and on reproduction.

HealthyStuff this site provides information about toxic chemicals that can be found in everyday items such as toys, children's car seats, jewelry, and building materials.  It has a searchable database and reports on specific types of products.

Safer Chemicals, Healthy Families this is a consumer watchdog and advocacy group working to reduce exposure to toxic chemicals in the US.  The site contains information and news releases about toxic chemicals.

The Collaborative on Health and the Environment has a database that allows you to select a disease and see which toxic chemicals are associated with it, ranked by how strong the evidence is to support the link.

This page from the National Institute of Environmental Health Sciences discusses chemicals that are endocrine disrupters, including what they are and how they work.  Chemicals with endocrine disrupting abilities include BPA, some flame retardants, dioxins, many pesticides, PCBs, and many more.

This page from TACA (Talk About Curing Autism) has information about some specific toxins found in our food supply and environment.

This post from The Autism File called Green Home…Healthy Kids gives more information on a wide variety of hazardous chemicals found in and around our homes, such as personal care products, cleaning products, and electronics.

It turns out that many of these harmful chemicals are ending up in human breastmilk and being passed along to babies at a susceptible age.

GENERAL AND WIDESPREAD SOURCES OF TOXICITY
The Minderoo-Monaco Commission on Plastics and Human Health
"Plastics have conveyed great benefits to humanity and made possible some of the most significant advances of modern civilization in fields as diverse as medicine, electronics, aerospace, construction, food packaging, and sports. It is now clear, however, that plastics are also responsible for significant harms to human health, the economy, and the earth's environment. These harms occur at every stage of the plastic life cycle, from extraction of the coal, oil, and gas that are its main feedstocks through to ultimate disposal into the environment. The extent of these harms not been systematically assessed, their magnitude not fully quantified, and their economic costs not comprehensively counted."

Human Health and Ocean Pollution
"Pollution - unwanted waste released to air, water, and land by human activity - is the largest environmental cause of disease in the world today. It is responsible for an estimated nine million premature deaths per year, enormous economic losses, erosion of human capital, and degradation of ecosystems. Ocean pollution is an important, but insufficiently recognized and inadequately controlled component of global pollution. It poses serious threats to human health and well-being. The nature and magnitude of these impacts are only beginning to be understood. "

"Methylmercury and PCBs are the ocean pollutants whose human health effects are best understood. Exposures of infants in utero to these pollutants through maternal consumption of contaminated seafood can damage developing brains, reduce IQ and increase children's risks for autism, ADHD and learning disorders. Adult exposures to methylmercury increase risks for cardiovascular disease and dementia."

"Manufactured chemicals - phthalates, bisphenol A, flame retardants, and perfluorinated chemicals, many of them released into the seas from plastic waste - can disrupt endocrine signaling, reduce male fertility, damage the nervous system, and increase risk of cancer. HABs produce potent toxins that accumulate in fish and shellfish. When ingested, these toxins can cause severe neurological impairment and rapid death. HAB toxins can also become airborne and cause respiratory disease."

PHTHALATES and PLASTICS
The website Toxic-Free Future has specific information about phthalates, where we are exposed to them, and how to reduce our exposure.  Phthalates are not chemically bound to the products they're in so they easily migrate out and contaminate the products and environment around them.The site has a section with research-based reports on a variety of topics around human health and toxic exposure that are worth checking out. 

"Because phthalates are so widely used in building materials as well as products used indoors, they are widespread indoor pollutants. Products like vinyl flooring, shower curtains, and toys release phthalates over time to the air and they build up in dust. With their greater hand-to-mouth behavior and more contact with the floor, children are likely to have greater exposure through ingesting contaminated dust."

"Studies by the CDC find that women consistently have higher exposure to certain phthalates, likely because of greater use of phthalate-containing cosmetics and personal care products. Women of color have particularly high exposures to these phthalates."

"Phthalates are well-known for their ability to disrupt the hormonal system, with extensive laboratory research concluding that exposure to phthalates reduces testosterone levels and leads to an array of male reproductive problems. Effects include malformations in organs needed for sperm development, hypospadias (abnormal urinary openings), and undescended testes. Studies in people provide evidence that exposure levels are already high enough that they may be harming male reproductive development."

Phthalates and attributable mortality: A population-based longitudinal cohort study and cost analysis
"Cardiovascular mortality was significantly increased in relation to a prominent DEHP metabolite, mono-(2-ethyl-5-oxohexyl)phthalate. Extrapolating to the population of 55–64 year old Americans, we identified 90,761–107,283 attributable deaths and $39.9–47.1 billion in lost economic productivity."

"In a nationally representative sample, phthalate exposures were associated with all-cause and cardiovascular mortality, with societal costs approximating $39 billion/year or more. While further studies are needed to corroborate observations and identify mechanisms, regulatory action is urgently needed."

Forever Toxic: The science on health threats from plastic recycling

How to avoid toxic chemicals hidden in your food, makeup, and toiletries that affect hormones and increase your risk of early death
"Ortho-phthalates, or phthalates for short, are a family of chemical compounds that can be found in hundreds, if not thousands, of the products you buy.  The synthetic chemicals are commonly used to soften plastic into bendy vinyl, and they can achieve the same plasticizing effect in nail polish and hairspray. But in humans, too much exposure to phthalates can get in the way of important hormone function."

The EPA has a voluntary program called Safer Choice that certifies personal care and household products that have met it's guidelines for safety of ingredients.  The criteria for meeting the standard are listed in this document, but are not easy to summarize.  The list of approved products can be searched here Search the EPA's Safer Choice Standard List of Products

PERSONAL CARE PRODUCTS:
The Environmental Working Group's (EWG's) Skin Deep database has information about toxic chemicals in personal care products such as cosmetics, shampoo, and sunscreen.

This page from EWG
has specific and updated information about safety testing sunscreens.

Lead, cadmium, arsenic, and other heavy metals in toothpaste

8 Products That Contain Endocrine Disrupting Chemicals (And How To Avoid Them)

The Cost of Inaction: A Socioeconomic analysis of costs linked to effects of endocrine disrupting substances on male reproductive health

Supplements can be a source of lead and other toxins

TOXICITY IN WATER:
The EPA has a website called AirNow that gives you information about the air quality in your specific area.

Health Effects of Lead Exposure (from the CDC)
"No safe blood lead level in children has been identified. Even low levels of lead in blood have been shown to negatively affect a child’s intelligence, ability to pay attention, and academic achievement."

"Lead exposure occurs when a child comes in contact with lead by touching, swallowing, or breathing in lead or lead dust."

Environmental Working Group's National Drinking Water Database allows you to search by zip code to find out what is in local drinking water. 
 
 
In a first, EPA survey puts a number on lead pipes around US
"Some 9.2 million lead pipes carry water into homes across the U.S., with more in Florida than any other state, according to a new Environmental Protection Agency survey."
 
"Around the country, utilities have been leaving lead pipe in the ground even when it is easiest to remove during water main work. Worse, they have been removing sections, disturbing the pipe and leaving the rest, which can spike lead levels, causing harm that will last a lifetime, an investigation by The Associated Press has found."
 
Michigan city on edge as lead water crisis persists
This situation is happening in hundreds of cities across the US.  From the article "federal officials say no amount of lead in drinking water is considered safe for their consumption."
 
Predictions of groundwater PFAS occurrence at drinking water supply depths in the United States
"Per- and polyfluoroalkyl substances (PFAS), known colloquially as “forever chemicals,” have been associated with adverse human health effects and have contaminated drinking water supplies across the United States owing to their long-term and widespread use. People in the United States may unknowingly be drinking water that contains PFAS because of a lack of systematic analysis, particularly in domestic water supplies. We present an extreme gradient–boosting model for predicting the occurrence of PFAS in groundwater at the depths of drinking water supply for the conterminous United States. Our model results indicate that 71 million to 95 million people in the conterminous United States potentially rely on groundwater with detectable concentrations of PFAS for their drinking water supplies before any treatment."
An interactive map to accompany this study

Plastics Toxic River: The EPA's Failure to Regulate Wastewater From the Petrochemical Plants That Make Plastic
"Environmental harm from plastics is widespread throughout its lifecycle – from the extraction, transportation, and refining of the raw fossil-fuel ingredients, to the manufacturing of plastic products, to the management of waste. The industry’s pollution litters and contaminates our water, air, food, and even our bodies.

Despite this increasingly harmful footprint, plastics manufacturers have mostly escaped having to use modern pollution controls to clean wastewater before it is dumped into waterways. Though federal rules limit some pollutants, many harmful chemicals released by plastics manufacturers are completely unregulated by the U.S. Environmental Protection Agency (EPA) – including contaminants that scientists have identified as carcinogenic or otherwise harmful to human health. These include dioxins, which are known cancer-causing agents that are highly toxic and persist in the environment; 2 and 1,4-dioxane, a likely carcinogen that EPA scientists recently indicated is threatening drinking water sources. 3 Nitrogen and phosphorus pollution discharged from plastics and petrochemical plants – which cause algal blooms and fish-killing low-oxygen zones – are also not controlled by EPA’s industrial wastewater rules. Although state agencies can set limits for these pollutants in individual wastewater discharge permits, practices vary across states and the limits are inadequate and inconsistent."

Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid or Perfluorooctane Sulfonate
Extensive report of research regarding the health effects of PFAS "forever chemicals".
This page has more info about PFAS
 
"PFAS, or per- and polyfluorinated substances, are a group of compounds that are widespread, dangerous and expensive to remove from water. They don’t degrade in the environment and are linked to a broad range of health issues, including low birth-weight and kidney cancer."
 
Study: "Forever chemicals" detected in nearly half of U.S. tap water
"At least 45% of U.S. tap water is estimated to be contaminated with "forever chemicals," according to new U.S. Geological Survey research.
 
"Forever chemicals" linked to elevated blood pressure, study says
"Women in the highest one-third concentrations of all seven PFAS examined had a 71% increased risk of developing high blood pressure."
From Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation

 
TOXICITY IN AIR and AIR POLLUTION 
 
Gas Stove Smoke Accounts for 12% of Childhood Asthma in the US, Study Finds
"The study found that 12.7% (95% CI, 6.3%-19.3%) of current childhood asthma is attributable to gas stove use."
 
Methane and NOx Emissions from Natural Gas Stoves, Cooktops, and Ovens in Residential Homes
"In addition to methane emissions, co-emitted health-damaging air pollutants such as nitrogen oxides (NOx) are released into home air and can trigger respiratory diseases."

This Newsweek article about spraying pesticides to control West Nile Virus provides a lot of information about how spraying for pests in urban areas is done, the ways in which it is evaluated for safety, and some of the ill effects on humans.

Neurotoxicity of traffic-related air pollution
"The central nervous system is emerging as an important target for adverse health effects of air pollution, where it may contribute to neurodevelopmental and neurodegenerative disorders. Air pollution comprises several components, including particulate matter (PM) and ultrafine particulate matter (UFPM), gases, organic compounds, and metals. An important source of ambient PM and UFPM is represented by traffic-related air pollution, primarily diesel exhaust (DE). Human epidemiological studies and controlled animal studies have shown that exposure to air pollution, and to traffic-related air pollution or DE in particular, may lead to neurotoxicity. In particular, air pollution is emerging as a possible etiological factor in neurodevelopmental (e.g. autism spectrum disorders) and neurodegenerative (e.g. Alzheimer's disease) disorders. The most prominent effects caused by air pollution in both humans and animals are oxidative stress and neuro-inflammation. Studies in mice acutely exposed to DE (250–300 μg/m3 for 6 h) have shown microglia activation, increased lipid peroxidation, and neuro-inflammation in various brain regions, particularly the hippocampus and the olfactory bulb. An impairment of adult neurogenesis was also found. In most cases, the effects of DE were more pronounced in male mice, possibly because of lower antioxidant abilities due to lower expression of paraoxonase 2."
 
Association between short-term ambient air pollution and outpatient visits of anxiety: A hospital-based study in northwestern China
"short-term exposure to ambient air pollutants, especially gaseous air pollutants (NO2 and SO2), can be related to higher risk of anxiety outpatient visits."
 
Association between air pollution and menstrual disorder outpatient visits: A time-series analysis
"This is the first evidence that short-term exposure to ambient air pollution can be associated with an increased risk of menstrual disorder attacks. The results of our study may help to establish more comprehensive understanding of the health effects of ambient air pollution on menstrual disorders and other reproductive diseases."
"The combustion of fossil fuels (coal, petroleum [oil], and natural gas) is the major source of both air pollution and the greenhouse-gas emissions driving climate change. The fetus, infant, and child are especially vulnerable to exposure to air pollution and climate change, which are already taking a major toll on the physical and mental health of children. Given the frequent co-occurrence of various fossil-fuel exposures, their interactions and cumulative environmental impacts are a growing concern. All children are at risk, but the greatest burden falls on those who are socially and economically disadvantaged. Protection of children’s health requires that health professionals understand the multiple harms to children from climate change and air pollution and use available strategies to reduce these harms."

"The data are compelling that the toll on children and pregnant women from fossil-fuel–driven climate change and air pollution is large and growing, affecting immediate and long-term health. Interventions — which are, in many cases, cost-saving — exist to address the causes of climate change and air pollution and the disparities that they have created. Health professionals have the power to protect the children they care for by screening to identify those at high risk for associated health consequences; by educating them, their families, and others more broadly about these risks and effective interventions; and by advocating for strong mitigation and adaptation strategies."

HOUSEHOLD PRODUCTS:
The US Department of Health and Human Services Household Products Database has health and safety information for many types of household products such as cleaning chemicals, fertilizers, auto products, and arts and crafts materials.  The entries have information from the product labels and MSDS (Material Safety Data Sheet) put out by the manufacturer, as well as contact info for the manufacturer.

Environmental Working Group's Guide to Healthy Cleaning is a database with health and safety information for more than 2500 cleaning products.

Low levels of common flame-retardant chemical damages brain cells
"The study showed that even tiny amounts of the compound damage neural mitochondria, the energy plants that power our cells. The chemical, quite literally, reduces brain power. In addition, the researchers found that the loss of PTEN protein, a condition associated with autism-like behavior in mice, combined with BDE-49 exposure, makes neurons even more susceptible to mitochondrial damage. These findings bolster the argument that genetics and environment can combine to increase the risk of autism and other neurological disorders."  

The use of household cleaning products during pregnancy and lower respiratory tract infections and wheezing during early life.

Int J Public Health. 2013 Oct;58(5):757-64.
"The period prevalence of LRTI was higher when sprays (combined odds ratio (OR) = 1.29; 95 % confidence interval (CI) 1.04-1.59) or air fresheners (OR = 1.29; CI 1.03-1.63) were used during pregnancy. The odds of wheezing increased with spray (OR = 1.37; CI 1.10-1.69) and solvent (OR = 1.30; CI 1.03-1.62) use. The associations between spray and air freshener use during pregnancy and both outcomes remained apparent when these products were not used after pregnancy. Nevertheless, the estimates were higher when post-natal exposure was included.  The use of cleaning sprays, air fresheners and solvents during pregnancy may increase the risk of wheezing and infections in the offspring."

HOLIDAY
 
Christmas Tree Lights and ornaments can be high in lead (these are just a few examples)  National Tree Company makes lead-free and antimony-free artificial trees, and Holiday LEDS makes lead-free lights (but they are LED).

Artificial or Real Christmas Tree? What’s better for you and the environment.
Artificial trees are often made from PVC, which is a source of both lead and phthalate exposure, and are generally treated with flame retardants that are toxic.  These toxic substances migrate out of the tree and become part of household dust, which can then be inhaled or consumed.  Children and pets are at highest risk from the toxins in dust because they are more likely to put things in their mouths directly or get dust in their mouths that was on their hands or other objects they put in their mouths.  There are precautions you can take, according to this article:

"Don’t panic! If you are an owner of an artificial Christmas tree made out of PVC, there are precautions you can take to reduce your family’s exposure to lead and phthalates.
  1. When you first get your artificial tree, let it air out outside or in the garage before bringing it inside! You want the plastic-like smell to dissipate (these are VOCs and not good for indoor air!).
  2. Try using gloves when handling the tree and wash your hands before you snack and eat.
  3. Don’t let children play with the tree. After you decorate the tree, have it remain just that, a decoration! And of course, wash your children’s hands before they eat or snack.
  4. Vacuum with a HEPA filter regularly. This will ensure that any chemicals are sucked away!"
"If you’re currently tree-less and in the market for an artificial one, consider purchasing a tree made out of polyethylene (PE) or polypropylene (PP). These plastics are safer than PVC, with less chance for lead contamination and less additive like phthalates. Please check with the manufacturer, as there are many trees that are a mix of PVC and these safer plastics. Try to get a tree with as high of a percentage or polyethylene or polypropylene plastic as possible. You can also look for artificial trees from a retailer that has a good chemicals policy, like Ikea that can give you some peace of mind over the materials and sustainability of your purchase."

OTHER SOURCES:
Creativity Without Chemicals has information about choosing safer children's art and craft supplies, many products on the market contain solvents, heavy metals, formaldehyde preservatives, and phthalates.  The site has general suggestions, such as not using your kitchen items or surfaces for projects, not allowing kids to eat and drink while doing projects (or use caution and wash hands),   More specific advice includes:
"Choose water-based watercolors, tempera paints, and “non-gel” acrylics; avoid oils and enamels. Gel acrylics can contain toxic ammonia stabilizers and formaldehyde preservatives."

"Glue sticks, library paste, Elmer’s Glues, and adhesive tape are safer products to use. Rubber cement, model glues, and epoxy are solvent-based and should be avoided."

"Most crayons are made of paraffin, a petroleum product."  Crayons made of beeswax or soy are safer options.  Some brands of crayons have been found to contain asbestos, see this site for more information. 

"Choose coloring pencils instead as even water-based markers commonly contain various alcohols, which release vapors that can be inhaled. If markers are a must, then choose water-based markers and look for the AP symbol. Permanent markers typically contain toxic solvents like xylene."

"Avoid Sculpey or Fimo clays, both of which are PVC-based."  There are recipes online for making your own clay and "play doh" from scratch.

"Make your own (paper mache) using plain recycled paper and white glue. Steer clear of newspapers to avoid heavy metals and pigments from the inks. Pre-made kits use talc, which could contain asbestos impurities.

"The word “non-toxic “ and the AP or CP symbols on products are clues that these are less toxic options to very hazardous products, though still not always completely safe for kids."

"Read labels to check for certifications, ingredients, and cautionary statements, but remember that companies are not required to list all ingredients."

"Products with a Proposition 65 warning are not suitable for children."

This link has information on the potential toxic ingredients of many different kinds of art products for adults and artists.
         
Toxins found in school supplies, especially PVC and vinyl.
 
Toxic flame retardants in TVs
"In a 2017 study co-authored by Toxic-Free Future and Clean Production Action, it was found that TVs continue to contain toxic flame retardants that can escape the TV and contaminate house dust in homes. Adults and children are then exposed to the chemicals when they ingest the dust during everyday activities, like hand-to-mouth activity."  See the results here.  "Two of the TVs – one made by Element and one made by Samsung – contained the PBDE flame retardant deca-BDE, despite its being banned in five states. Those states are Washington, Maine, Oregon, Vermont, and Maryland. The TVs in the study were purchased in Washington." 

The hidden costs of forever chemicals in stain- and water-resistant products
"
A new study released by Toxic-Free Future finds toxic chemicals in most products labeled stain- or water-resistant, with 72% testing positive for PFAS (per- and polyfluoroalkyl substances). Items that were found to contain “forever chemicals” include rain jackets, hiking pants, mattress pads, comforters, napkins, and tablecloths."

How Safe is the Artificial Turf Your Child Plays On?
After it was discovered that what seemed like a relatively high percent of soccer goalies are developing blood cancers, especially lymphoma, questions are being raised about how safe artificial turf actually is. Specifically, the questions are around these tiny pieces of rubber, made from old car tires, that are spread on the field to make it softer. While many athletes have contact with the rubber pellets (called "crumb rubber"), goalies seem to have a much higher exposure because they dive for the field so much. They end up ingesting it and having it get caught in scrapes and cuts. Used tires are known to be toxic- "according to the EPA, mercury, lead, benzene, polycyclic aromatic hydrocarbons, and arsenic, among several other chemicals, heavy metals, and carcinogens, have been found in tires." Crumb rubber is also used on many playgrounds.

Industry slow to end use of toxic chemical cleaner TCE for vapor degreasing, while US EPA delays action on its proposed ban
"
Vapor degreasing is a process used in commercial settings to clean equipment or other items with hot vapor. TCE is heated, condenses onto parts placed in the degreasing unit, and carries contaminants away from those parts as it drips off. 

According to EPA, between 45,000 and 107,000 workers, including 454 to 1,066 pregnant women, are at risk for serious adverse health effects from exposure to TCE used in vapor degreasing processes where they work or nearby. TCE poses serious health dangers, including fetal heart defects and cancer."


Babies may receive excessive radiation from x-rays.


Saturday, April 25, 2015

Are We Allergic to Food or What's Been Done to it?

This TED talk by Robin O'Brien, who worked as a financial analyst who covered the food industry before having kids and becoming an advocate for people with food allergies after her youngest child developed a food allergy.  She has been called "food's Erin Brokovich".

Food allergies on dramatic rise-
From 1997 to 2002 peanut allergies doubled.  From 1997 to 2007 there has been a 265% increase in the rate of hospitalizations due to food allergies.  19% of school children have a food allergy.

Are we allergic to food or what's been done to it?
It didn't used to be that way- what changed?

She began paying attention to labels and food additives- "you swap out the real stuff, put the fake stuff in, it drives profitability...it preserves shelf life."  The question she never asked as an analyst is "is this stuff safe and what is it doing to our kids?".

The health of the current generation of kids-
1 in 3 has allergies, asthma, ADHD, or autism.
1 in 13 has food allergies
1 in 10 has asthma
1 in 68 has autism
"cancer is the leading cause of death by disease in American children under the age of 15." (according to CDC)

Genetically modified foods-

41% of Americans are expected to get cancer in our lifetime.
1 in 2 men and 1 in 3 women are expected to get cancer in the US.
Only 1 in 10 breast cancers are genetic.

In 1996 GMO ingredients were introduced into our food supply in the US without us being told and without labeling.  They were completely new to our food.  There were two kinds of GMO crops at the time, those that are designed to withstand increasing amounts of chemicals, and those that make their own pesticides.  The second kind is regulated by the EPA as a pesticide and was added to our food supply without us being told.  From a business model this was very successful and profitable, it drove a huge increase in sales of related chemicals.  This change resulted in hundreds of millions of pounds of additional chemicals being used on our food supply.  60% of the world's population was told about this, not us.  Why?  There were no long term human safety studies.  She wonders "is this a food system or a chemical system?".

"A food system dependent on chemicals is not a food system, it's a chemical system".  

Correlation does not mean causation, but the correlation is so strong that it merits further investigation.  Other countries around the world have exercised caution because they ARE concerned about potential health consequences and allergenicity of GMO foods.

What is different in countries where these ingredients are either labeled or banned?

American companies that have added such ingredients to the food supply in this country, including artificial dyes, flavors, and GMO ingredients, make these same products for sale in other countries without these ingredients.

"Why have they placed a different value on the lives of Americans?  If they're using all of these artificial ingredients here, and they're using real ones in other countries.  We're not asking them to reinvent the wheel.  We're simply asking for those same products for our families too."

"The United States spends two-and-a-half times more on health care and disease management, on average, than any other country".  Despite this spending, the US ranks number 42 in life expectancy at birth.

She says we need a new model-

What about organic food?  Really that just means food without all the artificial additives, or what used to be simply considered "food".  Organic costs more because as a nation we subsidize the artificial and chemically treated food.  Organic food is often brought in from other countries rather than being grown here.  She says we need to bring it home here, to support american farmers.  Clean and safe food should be available to all Americans.

What can we do?  Take small steps, don't be paralyzed by the enormity of the problem.  She advises to start by taking out one thing- artificial dyes, GMOs, etc, but just take a step.  "None of us can do everything, but all of us can do something."  As we make these changes, out economy is responding.

Friday, April 3, 2015

Childhood Stress and Trauma Sets the Stage for Health Throughout Our Lifetime

As a pediatrician working in one of San Francisco's poorest and most underserved neighborhoods, Dr Nadine Burke Harris became aware of the significant impact that childhood trauma has on the health of children.  Here she talks about the research showing that not only was she right, the problem is much bigger than that- it turns out that significant trauma in childhood is the single most accurate predictor of a person's health throughout their lifetime.  In this TED talk she discusses that research and why these traumas have the effect that they do:

How Childhood Trauma Affects Health Across a Lifetime

Significant childhood traumas, here referred to as ACEs for Adverse Childhood Experiences, have been shown to:
-increase the risk for 7 out of 10 of the leading causes of death in the US.
-affect brain development, the immune system, the hormonal system, and even the way our DNA is read and transcribed.
-increase the risk of heart disease and lung cancer by a factor of 3.
-shorten life expectancy by 20 years..

She also has a MA degree in public health, and she says that one thing that she learned in that program is that if there is a well, and 98 of 100 kids who drink from it develop diarrhea, as a doctor you can either write prescription after prescription for antibiotics or you can try to figure out what is in the well.  You can use the health outcomes as a clue to fix underlying problems and risks.

The Adverse Childhood Experiences study was done as a collaboration between doctors at Kaiser and the CDC.  It defined ACEs as physical, emotional, or sexual abuse: physical or emotional neglect: parental mental illness, substance dependence, incarceration: parental separation or divorce, or domestic violence.  The ACE score is a measure of how many of these events a person has experienced.  They found a dose-related correlation with health problems throughout life.

Some of the risk correlations that they found for someone with an ACE score of 4 or more include:
2.5 times the risk for COPD and Hepatitis,
4.5 times for depression
12 times for suicide attempts

For someone with an ACE score of 7 or more, the risks are:
3 times the risk for lung cancer,
3.5 times the risk of ischemic heart disease (the number 1 killer in the US),

Some people tried to write this off as a correlation that results from people who had "rough childhoods" making "poor decisions" about their health, and/or engaging in more risky behavior.  This turns out not to be the reason for the correlation.  It is more direct.  For example, this stress affects brain development, such as the the area called the nucleus accumbens that is involved in pleasure and reward and is implicated in substance abuse.  It inhibits the prefrontal cortex which is responsible for executive function and impulse control and important for learning.  Measurable differences can also be seen in the amygdala, the part of the brain that processes emotions and fear.  All of this is to say that there are real biological reasons why people with higher ACE scores might engage in more risky behavior.

However, the risks from ACEs are still there regardless of whether someone engages in risky behavior or not.  The reason for this has to do with the Hypothalamic-Pituitary-Adrenal system, the brain's stress-response system, and the part that controls the fight/flight response.  If you perceive threat, your hypothalamus sends a signal to your pituitary, that then sends a signal to your adrenal glands to respond by releasing stress hormones such as adrenaline and cortisol.  If this system is chronically activated it can go from being an adaptive response to one that is maladaptive and damaging to health, and children are especially sensitive to this.  Because children's bodies are still growing and developing, these ACEs not only affect the brain but also the immune system, the hormonal system, and even our epigenetics- which is the way that our DNA is read and transcribed.

She says it is the job of doctors to use information such as this- information about the causes of disease and poor health outcomes- for treatment and prevention.  In San Francisco she helped found the Center for Youth Wellness, to identify and support kids who need help recovering from ACEs.  They provide home care, mental health services, nutritional services, medication, and other interventions to try to reduce the impact of the ACEs.  Dr Robert Block, former president of the American Academy of Pediatrics, said "Adverse Childhood Experiences are the single greatest unaddressed public health threat facing our nation today".  Why is this information not being addressed?  Is it the perception that this is a problem for "other people"?  The original ACEs study was done in a population that was 70% Caucasian and 70% college educated, so it's not an issue of "those people"- it affects everyone.  Are we in denial?  We need the courage to take this problem seriously.

You can take a quiz on the NPR site to find out your ACE score.  This site has some basic info about what the score means and other factors that also influence health outcomes, such as resiliency.  It also has links to the CDC site about the ACE study and other relevant research.

More on this topic:

How Stress Effects Your Brain (a TED talk/lesson, gives the basics)

The type of PTSD that arises from chronic stress, abuse, or neglect in childhood is bow being called Complex PTSD (or C-PTSD for short).  This is a distinct form of PTSD and not just PTSD that arises from complex factors.  The difference is explained well in this video
C-PTSD vs PTSD - How are they Different?

Childhood, disrupted: Adversity in childhood can create long-lasting scars, damaging our cells and our DNA, and making us sick as adults
"New findings in neuroscience, psychology and immunology tell us that the adversity we face during childhood has farther-reaching consequences than we might ever have imagined. Today, in labs across the country, neuroscientists are peering into the once-inscrutable brain-body connection, and breaking down, on a biochemical level, exactly how the stress we experience during childhood and adolescence catches up with us when we are adults, altering our bodies, our cells, and even our DNA."

"...when children or teens face adversity and especially unpredictable stressors, they are left with deeper, longer‑lasting scars. When the young brain is thrust into stressful situations over and over again without warning, and stress hormones are repeatedly ramped up, small chemical markers, known as methyl groups, adhere to specific genes that regulate the activity of stress‑hormone receptors in the brain. These epigenetic changes hamper the body’s ability to turn off the stress response. In ideal circumstances, a child learns to respond to stress, and recover from it, learning resilience. But kids who’ve faced chronic, unpredictable stress undergo biological changes that cause their inflammatory stress response to stay activated."


This article from Psychology Today gives a more detailed explanation of some of the biological mechanisms responsible for the effects of early stress on the brain.

It's been found that trauma in adulthood is also associated with increased inflammation and disease.

The Science of Stress and How Our Emotions Affect Our Susceptibility to Burnout and Disease
This article is a really good discussion about how stress affects our mental and physical health, and our immune system specifically, and the ways in which they are connected.  It gives some history about how the emotions and physical health were seen as interconnected in many societies in the past, but in the west Descartes' rationalism separated mind from body.  It then discusses the work of Dr Esther Sternberg whose groundbreaking work looking at the interconnection between the central nervous system and immune system has brought the interconnection between the mind and body back into western thought.  It goes on to talk about how memories play a role in how we respond to stress, how acute stress and chronic stress differ biochemically, and how destructive chronic stress is to our bodies.  Lastly, there is mention of how social relationships can help shield us from the effects of stress.  For more on the protective effects of social networks read this page about recent research into the strong degree to which strong social support reduces our health risks.

How Child Abuse Primes the Brain for Future Mental Illness

"Now, in the largest study yet to use brain scans to show the effects of child abuse, researchers have found specific changes in key regions in and around the hippocampus in the brains of young adults who were maltreated or neglected in childhood. These changes may leave victims more vulnerable to depression, addiction and post-traumatic stress disorder (PTSD), the study suggests.

...chronic maltreatment can set the stress system permanently on high alert. That may be useful in some cases — for example, for soldiers who must react quickly during combat or for children trying to avoid their abusers — but over the long term, the dysregulation increases risk for psychological problems like depression and PTSD."


This is the study discussed in this article:
Chronic stress and anxiety can damage the brain, increase the risk of major psychiatric disorders

Stress lies at the heart of disease, addiction
"...we must move beyond the individual model of illness to embrace what he terms a “biopsychosocial” explanation, in which the mind, body and society are seen as an interacting continuum. Cancer, for instance, is usually caused by a number of factors, which may include toxins in our environment, chronic stress, and social isolation. Genes, he added, “can pre-dispose, but not pre-determine” who will get sick.

Mate mentioned a study of breast cancer in women, which found that those who were both over-stressed and lacked strong social connections had a cancer rate nine times higher than women who were stressed but had strong social bonds, as well as those who had weak connections but were not stressed.

Chronic stress — from overwork, poverty, abuse and so on — suppresses the normal function of a person’s immune system, increasing the risk of a host of illnesses."

Biological embedding of stress through inflammation processes in childhood
"Children exposed to adverse psychosocial experiences show elevated disease risk in adulthood. It is therefore important to characterize the biological mechanisms through which children may acquire such lasting vulnerability to disease, namely, the mechanisms of biological embedding."

Early Mortality and Primary Causes of Death in Mothers of Children with Intellectual Disability or Autism Spectrum Disorder: A Retrospective Cohort Study
"During the study period, mothers of children with intellectual disability or ASD had more than twice the risk of death. Mothers of children with intellectual disability were 40% more likely to die of cancer; 150% more likely to die of cardiovascular disease and nearly 200% more likely to die from misadventure than other mothers. Due to small numbers, only hazard ratios for cancer were calculated for mothers of children with ASD. These mothers were about 50% more likely to die from cancer than other mothers. Possible causes and implications of our results are discussed."

This post on the blog Questioning Answers talks about the above study.
"A few other details are also recorded in the Fairthorne study. "Mothers with both a psychiatric disorder and a child with intellectual disability or ASD had about six and a half times the risk of death" was an important finding reported by the authors. When it came to the cause of death, various factors were over-reported in case group mums including cancers, cardiovascular disease and death by misadventure (death due to an unintentional accident, homicide or suicide according to the authors' criteria)."

How Stress Is Making You Lose Your Mind
"The stress hormone cortisol can kill, shrink, and stop the generation of new neurons in a portion of the brain called the hippocampus.  The hippocampus is critical for learning, memory and emotional regulation, as well as shutting off the stress response after a stressful event is over: all much-needed processes in both our professional and personal lives.

Chronic stress can also shrink the medial prefrontal cortex.  This negatively affects decision making, working memory, and control of impulsive behavior. Stress also has the ability to affect stem cells, inhibiting access to the prefrontal cortex, where we plan complex cognitive behavior and moderate social interaction. The result is a brain that is less capable of learning and memory, and more prone to anxiety and depression.

To make matters worse, these same stress hormones can increase the size and activity of a portion of the brain called the amygdala.  The amygdala is critical in the formation and storage of memories associated with highly emotional events. It pairs an event with a feeling, and this connection is stored away in our long-term memory so we can either avoid the event or seek it out in the future. The changes cortisol creates increase negative emotions such as fear, anxiety, and aggression."

This article also talks about the effectiveness of exercise in reversing these effects.

Adverse childhood events appear to increase the risk of being a hypertensive adult
"Children who experience multiple traumatic events, from emotional and sexual abuse to neglect, have higher blood pressures as young adults than their peers, researchers report. The difference of 10 points in the systolic pressure -- the top number denoting pressure while the heart is contracting -- by early adulthood puts these young people at higher risk for hypertension and coronary artery disease by middle and/or old age, said Dr. Shaoyong Su, genetic epidemiologist at the Medical College of Georgia at Georgia Regents University."

Sunday, November 9, 2014

Vertical Viral Transmission as Pathogenesis in Autism?

A study published in 2010 out of Rome, Italy has found evidence of vertical viral transmission in postmortem evaluations of the brains of people with autism.  The study was undertaken because there is evidence of heritability of autism, that is of it being passed along in families, that is stronger than the evidence that is being found for a genetic cause for this heritability.  So the question was asked, in what other ways could a disorder such as autism be passed from one generation to the next?  Infections are certainly one way that this can occur.  To quote from the study "Autism is a highly heritable behavioral disorder. Yet, two decades of genetic investigation have unveiled extremely few cases that can be solely explained on the basis of de novo mutations or cytogenetic abnormalities. Vertical viral transmission represents a non-genetic mechanism of disease compatible with high parent-to-offspring transmission and with low rates of disease-specific genetic abnormalities."

This study, Association of autism with polyomavirus infection in postmortem brains,
found that three viruses were significantly more prevalent in the brains of people with autism than in the controls "BKV, JCV, and SV40 combined are significantly more frequent among autistic patients compared to controls (67% versus 23%, respectively; P < .05). "  SV40 is Simian Virus 40, a monkey virus that was a contaminant in polio vaccines used between 1955 and 1963.  BK and JC viruses are closely related to each other, and are part of the family of polyomaviruses (which is a subgroup of papovaviruses). SV40 is also a papovavirus.

SV40 has long been suspected of causing cancer in humans, but evidence has been mixed and inconclusive.   The Immunization Safety Review Committee of the Institute of Medicine put out a report on this question that can be viewed here, which essentially says that the epidemiological evidence that has been used to deny a connection between SV40 and cancer is too flawed to rule out a possible connection, that the idea that SV40 could contribute to human cancers is plausible, and that ongoing investigation is required.

The paper "BK Virus: A Clinical Review" provides more information about BK virus:

-the etiologic agent of progressive multifocal leukoencephalopathy (PML).
-The kidney, lung, eye, liver, and brain are sites of BK virus-associated disease, both primary and reactivated.
-BK virus has also been detected in the tissue samples of a variety of neoplasms, which have predominantly been brain tumors of glial and neural origin, although there is controversy regrading associations between these neoplasms and BK virus.
-A few investigators have proposed various mechanisms whereby BK virus can induce neoplasia (cancer).
-There may even be an association between BK virus and autoimmune disease.
-Although rarely recognized, BK virus might cause both primary CNS disease and reactivation CNS disease as well.
-Additional disorders of the CNS associated with BK virus include encephalitis, Guillain-Barre Syndrome, and Meningoencephalitis.
-Many authors have reported that BK virus can exist in a latent phase in various organs [12–27]. Much of the data are based on PCR experiments; exceptions are mentioned below. Similar in concept to the latent state of the herpesvirus [101], these authors propose that BK virus can remain within a cell in a nonreplicating or minimally replicating form. Within the cell, the latent viral genome may either remain episomal or it may be integrated in the host cell genome. In either state, few if any viral genes are transcribed, thereby keeping the virus out of reach of the immune system. Implicit in the definition of latency is the concept of virus reactivation in certain settings.
-Reactivation disease is observed in patients with relative or absolute immunodeficiency (generally cellular immunodeficiency rather than humoral immunodeficiency).
-researchers reported an increased prevalence and persistence of BK viruria in patients with systemic lupus erythematosus. In their study, the prevalence of BK viruria was 16% in patients with systemic lupus erythematosus and 0% in controls. Of the 20 patients who were tested, persistent or recurrent viruria was found in 60% of patients with systemic lupus erythematosus [90]. This same relationship is seen between BK virus and other autoimmune diseases, including rheumatoid arthritis and polymyositis [117]. Although whether there is causality has not been determined.
-Although it is not proof of causality, the strongest data, including demonstration of viral DNA integration into tumor cell genomes, and even the findings of some in situ studies, support a correlation between BK virus and many brain and urinary tract tumors [66, 70, 87].
-Other researchers that have observed the same phenomenon from a different perspective have examined the association of BK viral infection with an increased number of chromosomal aberrations. The induction of chromosomal aberrations via BK virus T antigen is observed in vitro in human fibroblast cell lines [85]. Also, one study reported that a group of patients with polyomavirus infection who were exposed to radiation experienced a greater number of chromosomal aberrations than did a similar group of persons without infection [86].
-Moens et al. [88, 89] demonstrated indirect interaction between the large T antigen of BK virus and native cell estrogen receptors that, via trans activation, enhances the promoter of BK virus. The researchers postulated that there was a hormone-mediated association with BK virus reactivation and even neoplasia.

More on JC Virus:

From Understanding the JC VIrus and the Risks for MS Patients:
-The JC Virus is the cause of Progressive Multifocal Leukoencephalopathy (PML), in which "it infects the white matter of the brain and attacks the cells responsible for making myelin, the protective coating that covers and protects nerve cells.".  
-This virus can be triggered to reactivate either because the immune system of the person with MS is compromised, or because the person is taking immune-suppressing medications.  

More information on JC infection can be found here:

-Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system (CNS), caused by the polyoma virus JC virus (JCV) and characterized by focal demyelination.
-PML manifests as focal neurological deficits, usually with insidious onset and steady progression. Because the demyelinating lesions can involve different brain regions, specific deficits vary from patient to patient. Any region of the CNS can be involved, although some areas seem to be more favored, including the occipital lobes (with hemianopsia), frontal and parietal lobes (aphasia, hemiparesis, and hemisensory deficits), and cerebellar peduncles and deep white matter (dysmetria and ataxia).
-Spinal cord involvement is rare.
-Although lesions can be multiple, one often is clinically predominant.
-Initial symptoms and signs often begin as partial deficits (e.g., weakness in one leg) that worsen over time and involve a larger territory (e.g., evolution to hemiparesis) as individual lesions expand concentrically or along white matter tracts. The focal or multifocal nature of the pathology is responsible for the consistency of clinical presentations with distinct focal symptoms and signs, rather than as a more diffuse encephalopathy, or isolated dementia or behavioral syndrome, all of which are uncommon without concomitant focal findings.

The article JC Virus Infection of the Brain has some more updated information:

-Since its initial description, there have been significant changes in the epidemiology, pathogenesis, and clinical and imaging manifestations of JCV infection of brain. The most common clinical manifestation is PML. Other recently described CNS manifestations are JCE (JCV encephalopathy), JCVGCN (JCV Granular Cell Neuronopathy), and JCM (JCV Meningitis).
-Although AIDS is the most common predisposing factor for JCV reactivation, there is increasing incidence of brain manifestations of JCV reactivation in non-HIV settings, including different rheumatologic, hematologic, and oncologic conditions; monoclonal antibody therapy; transplant recipients; primary immunodeficiency syndromes; and even in patients without any recognizable immune deficiency.
-It has become evident that PML has outgrown its name. JCV infection is no longer a 1-dimensional opportunistic infection, limited to HIV and lymphoproliferative disorders. Although HIV accounts for approximately 80% of the PML cases, there is increasing incidence of the disease in non-HIV settings.
-JCV is a ubiquitous human pathogen, and both inhalation and ingestion of contaminated water have been suggested as major modes of transmission of the virus.
-Usually, severe deficiency of T-cell immunity (cellular immunity) is necessary for reactivation of JCV.
-Calabrese et al18 recently reviewed 37 cases of PML in the setting of rheumatic diseases. All patients in this series were treated with some form of immunosuppressant before PML manifestation. Of all the rheumatologic conditions SLE was most commonly associated (65%) with PML. Other associated rheumatic diseases were rheumatoid arthritis, Wegener granulomatosis, dermatomyositis, polymyositis, and scleroderma. There are also reports of PML in patients with Sjogren syndrome19 and sarcoidosis20 with no prior immunomodulator therapy. In both of these cases, there was associated lymphocytopenia. It is unclear whether the rheumatologic condition or the lymphocytopenia was responsible for PML.
-PML has also been described in patients with primary immunodeficiency disorders, ICL being the most common condition to be associated with PML.28–30 PML has also been described in patients with common variable immune deficiency.
-Until recently, severe depletion of cellular immunity was considered an absolute requirement for the development of PML. However, there are now case reports of PML with less overt immunodeficiency, such as cirrhosis, renal failure, psoriasis, dermatomyositis, and even pregnancy.6 Furthermore, there are multiple reports in the literature of PML without any documented immunodeficiency.6 It is very important that neuroradiologists be aware of this expanding demography of PML, JCE, JCVGCN, and JCM.
-The pathogenesis of PML is divided into 3 phases. The first phase is a primary clinically unapparent infection. In the second phase, the virus maintains a persistent latent peripheral infection in the urinary tract, bone marrow, and probably the spleen.35 The presence of JCV in the bone marrow and shedding of the virus in urine are well documented in asymptomatic immunocompetent carriers.36,37 The CNS has also been suggested as a potential site for JCV persistence. The third or final phase is that of reactivation and dissemination of the virus with presumed hematogenous spread to the CNS.
-The authors concluded that tests for BK virus and JCV should be included in the investigative program for patients with meningitis or encephalitis.
-PML may involve gray matter as well. The thalamus is the most common area, followed by the basal ganglia.49,88 Usually gray matter lesions are associated with white matter involvement in almost all cases. Vary rarely, PML lesions can be isolated to the gray matter.
-As briefly mentioned previously, PML can occur in MS patients treated with natalizumab. It is very difficult to differentiate a new PML lesion from an MS plaque in patients treated with natalizumab.

More interesting finds about BK virus, JC virus, and SV 40:

Hypothesis- "Rogue cell"-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncopenesis

Abstract- "The hemagglutination inhibition antibody titers against the JC and BK polyoma viruses (JCV and BKV, respectively) are significantly elevated in individuals exhibiting "rogue" cells among their cultured lymphocytes. However, the elevation is so much greater with respect to JCV that the BKV elevation could readily be explained by cross reactivity to the capsid protein of these two closely related viruses. The JCV exhibits high sequence homology with the simian papovavirus, simian virus 40 (SV40), and inoculation of human fetal brain cells with JCV produces polyploidy and chromosomal damage very similar to that produced by SV40. We suggest, by analogy with the effects of SV40, that these changes are due to the action of the viral large tumor antigen, a pluripotent DNA binding protein that acts in both transcription and replication. The implications of these findings for oncogenesis are briefly discussed."