(This is a pre-print, I will update this post as more information becomes available)
Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination
"To explore potential pathobiological features associated with PVS (Post-Vaccine Syndrome), we conducted a decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in the Yale LISTEN study. Compared with controls, PVS participants exhibited differences in immune profiles, including reduced circulating memory and effector CD4 T cells (type 1 and type 2) and an increase in TNFα+ CD8 T cells. PVS participants also had lower anti-spike antibody titers, primarily due to fewer vaccine doses. Serological evidence of recent Epstein-Barr virus (EBV) reactivation was observed more frequently in PVS participants. Further, individuals with PVS exhibited elevated levels of circulating spike protein compared to healthy controls. These findings reveal potential immune differences in individuals with PVS that merit further investigation to better understand this condition and inform future research into diagnostic and therapeutic approaches."
Protocol for Vaccine Injury Management (from Dr Been, based on Yale study)
